Thyroid Hormone Profile in Patients Ingesting Soft Gel Capsule or Liquid Levothyroxine Formulations with Breakfast
Joint Authors
Morassi, M. L.
Casella, Claudio
Cappelli, Carlo
Pirola, Ilenia
Gandossi, Elena
Castellano, Maurizio
Cristiano, Alessandra
Daffini, Linda
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Recently, it has been shown that liquid L-T4 formulation can be ingested with breakfast.
This study looked to extend these findings by investigating whether a soft gel capsule formulation of L-T4 could also be ingested at breakfast time.
Methods.
60 patients (18–65 yrs), previously submitted to thyroidectomy for proven benign goitre in stable euthyroidism receiving liquid L-T4 therapy ingested with breakfast, were enrolled.
TSH, fT4, and fT3 levels were assessed in all the patients who were switched from liquid L-T4 to a soft gel capsule formulation at the same dosage of L-T4.
After 6 months, TSH, fT4, and fT3 levels were determined again.
Results.
There were no differences in TSH levels, but fT3 and fT4 levels during treatment with the soft gel capsule were significantly lower than those at enrolment with the liquid L-T4 formulation (TSH median (min–max): 1.9 (0.5–4.0) versus 2.2 (0.5–4.5) mIU/L, fT3: 2.5 (2.4–3.1) versus 2.7 (2.4–3.3) pg/mL, p < 0.05 , and fT4: 9.9 (8.0–13) versus 10.6 (8.6–13.8) pg/mL, p < 0.0001 ).
Conclusion.
Both liquid and soft gel formulations of L-T4 can be taken with breakfast.
However, liquid L-T4 would be the preferred formulation for patients in whom even small changes in fT4 and fT3 levels are to be avoided.
American Psychological Association (APA)
Cappelli, Carlo& Pirola, Ilenia& Gandossi, Elena& Cristiano, Alessandra& Daffini, Linda& Morassi, M. L.…[et al.]. 2016. Thyroid Hormone Profile in Patients Ingesting Soft Gel Capsule or Liquid Levothyroxine Formulations with Breakfast. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1106042
Modern Language Association (MLA)
Cappelli, Carlo…[et al.]. Thyroid Hormone Profile in Patients Ingesting Soft Gel Capsule or Liquid Levothyroxine Formulations with Breakfast. International Journal of Endocrinology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1106042
American Medical Association (AMA)
Cappelli, Carlo& Pirola, Ilenia& Gandossi, Elena& Cristiano, Alessandra& Daffini, Linda& Morassi, M. L.…[et al.]. Thyroid Hormone Profile in Patients Ingesting Soft Gel Capsule or Liquid Levothyroxine Formulations with Breakfast. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1106042
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106042