Biology of Beige Adipocyte and Possible Therapy for Type 2 Diabetes and Obesity
Joint Authors
Lizcano, Fernando
Vargas, Diana
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
All mammals own two main forms of fat.
The classical white adipose tissue builds up energy in the form of triglycerides and is useful for preventing fatigue during periods of low caloric intake and the brown adipose tissue instead of inducing fat accumulation can produce energy as heat.
Since adult humans possess significant amounts of active brown fat depots and their mass inversely correlates with adiposity, brown fat might play an important role in human obesity and energy homeostasis.
New evidence suggests two types of thermogenic adipocytes with distinct developmental and anatomical features: classical brown adipocytes and beige adipocytes.
Beige adipocyte has recently attracted special interest because of its ability to dissipate energy and the possible ability to differentiate itself from white adipocytes.
Importantly, adult human brown adipocyte appears to be mainly composed of beige-like adipocytes, making this cell type an attractive therapeutic target for obesity and obesity-related diseases.
Because many epigenetic changes can affect beige adipocyte differentiation, the knowledge of the circumstances that affect the development of beige adipocyte cells may be important for therapeutic strategies.
In this review we discuss some recent observations arising from the great physiological capacity of these cells and their possible role as ways to treat obesity and diabetes mellitus type 2.
American Psychological Association (APA)
Lizcano, Fernando& Vargas, Diana. 2016. Biology of Beige Adipocyte and Possible Therapy for Type 2 Diabetes and Obesity. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106052
Modern Language Association (MLA)
Lizcano, Fernando& Vargas, Diana. Biology of Beige Adipocyte and Possible Therapy for Type 2 Diabetes and Obesity. International Journal of Endocrinology No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1106052
American Medical Association (AMA)
Lizcano, Fernando& Vargas, Diana. Biology of Beige Adipocyte and Possible Therapy for Type 2 Diabetes and Obesity. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106052
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106052