Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome
Joint Authors
Gibney, J.
McGowan, Anne
Phelan, Niamh
Correia, Neuman
Boran, Gerard
O’Connor, Anna-Louise
Roche, Helen M.
Kyaw Tun, Tommy
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Postprandial dyslipidaemia may be a plausible mechanism by which polycystic ovary syndrome (PCOS) increases cardiovascular risk.
We sought to investigate whether the postprandial glucose and insulin and lipid and lipoprotein responses, including that of apolipoprotein B-48 (apoB-48) containing chylomicrons, to a mixed meal are different in obese PCOS women when compared to obese control subjects and whether differences, if any, are related to obesity, insulin resistance (IR), hyperandrogenaemia, or PCOS status.
26 women with PCOS (age 30.4 ± 1.2 years (mean ± SEM), body mass index (BMI) 36.8 ± 1.5 kg/m2) and 26 non-PCOS subjects (age 34.1 ± 0.9 years, BMI 31.5 ± 1.0 kg/m2) were studied before and up to 8 hours following a standard mixed meal.
AUC-triglyceride (AUC-TG) was higher and AUC-high-density lipoprotein (AUC-HDL) lower in PCOS women.
These differences were not apparent when BMI was accounted for.
Insulin sensitivity ( S I ), AUC-apoB-48, and AUC-apolipoprotein B (AUC-apoB) were found to be independent predictors of AUC-TG, accounting for 55% of the variance.
Only AUC-insulin remained significantly elevated following adjustment for BMI.
Obesity related IR explains postprandial hypertriglyceridaemia and hyperinsulinaemic responses.
Management of obesity in premenopausal women with PCOS is likely to reduce their cardiovascular risk burden.
American Psychological Association (APA)
Kyaw Tun, Tommy& McGowan, Anne& Phelan, Niamh& Correia, Neuman& Boran, Gerard& O’Connor, Anna-Louise…[et al.]. 2016. Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1106053
Modern Language Association (MLA)
Kyaw Tun, Tommy…[et al.]. Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome. International Journal of Endocrinology No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1106053
American Medical Association (AMA)
Kyaw Tun, Tommy& McGowan, Anne& Phelan, Niamh& Correia, Neuman& Boran, Gerard& O’Connor, Anna-Louise…[et al.]. Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1106053
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106053