Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical Tablets
Joint Authors
Mbokou, Serge Foukmeniok
Pontié, Maxime
Tchieno, Francis Merlin Melataguia
Njanja, Evangeline
Mogni, Assad
Pontalier, Pierre Yves
Tonle, Ignas Kenfack
Bouchara, J.-P.
Source
International Journal of Electrochemistry
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Electrochemical determination of acetaminophen (APAP) was successfully performed using a carbon paste electrode (CPE) modified with coffee husks (CH-CPE).
Scanning electron microscopy (SEM) and SEM-energy dispersive X-ray spectroscopy (SEM-EDX) were, respectively, used for the morphological and elemental characterization of coffee husks prior to their utilization.
The electrochemical oxidation of APAP was investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV).
SWV technique appeared to be more sensitive since the oxidation current of APAP was twofold higher with the CH-CPE sensor than with the bare CPE, in relation to the increase in the organophilic character of the electrode surface.
Furthermore, on CH-CPE, the current response of APAP varied linearly with its concentration in the range of 6.6 μM to 0.5 mM, leading to a detection limit of 0.66 μM ( S / N = 3 ).
Finally, the proposed CH-CPE sensor was successfully used to determine the amount of APAP in commercialized tablets (Doliprane® 500 and Doliprane 1000), with a recovery rate ranging from 98% to 103%.
This novel sensor opens the way for the development of low-cost and reliable devices for the electroanalysis of pharmaceutical formulations in developing countries.
American Psychological Association (APA)
Mbokou, Serge Foukmeniok& Pontié, Maxime& Bouchara, J.-P.& Tchieno, Francis Merlin Melataguia& Njanja, Evangeline& Mogni, Assad…[et al.]. 2016. Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical Tablets. International Journal of Electrochemistry،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106078
Modern Language Association (MLA)
Mbokou, Serge Foukmeniok…[et al.]. Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical Tablets. International Journal of Electrochemistry No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1106078
American Medical Association (AMA)
Mbokou, Serge Foukmeniok& Pontié, Maxime& Bouchara, J.-P.& Tchieno, Francis Merlin Melataguia& Njanja, Evangeline& Mogni, Assad…[et al.]. Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical Tablets. International Journal of Electrochemistry. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106078