Transcriptomic Analysis of Resistant and Susceptible Bombyx mori Strains Following BmNPV Infection Provides Insights into the Antiviral Mechanisms
Joint Authors
Li, Gang
Qian, Heying
Luo, Xufang
Xu, Pingzhen
Yang, Jianhua
Liu, Mingzhu
Xu, Anying
Source
International Journal of Genomics
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
To decipher transcriptomic changes and related genes with potential functions against Bombyx mori nucleopolyhedrovirus infection and to increase the understanding of the enhanced virus resistance of silkworm on the transcriptomic level.
Methods.
We assembled and annotated transcriptomes of the Qiufeng (susceptible to infection) and QiufengN (resistant to infection) strains and performed comparative analysis in order to decipher transcriptomic changes and related genes with potential functions against BmNPV infection.
Results.
A total of 78,408 SNPs were identified in the Qiufeng strain of silkworm and 56,786 SNPs were identified in QiufengN strain.
Besides, novel AS events were found in these 2 strains.
In addition, 1,728 DEGs were identified in the QiufengN strain compared with Qiufeng strain.
These DEGs were involved in GO terms related to membrane, metabolism, binding and catalytic activity, cellular processes, and organismal systems.
The highest levels of gene representation were found in oxidative phosphorylation, phagosome, TCA cycle, arginine and proline metabolism, and pyruvate metabolism.
Additionally, COG analysis indicated that DEGs were involved in “amino acid transport and metabolism” and “carbohydrate transport and metabolism.” Conclusion.
We identified a series of major pathological changes in silkworm following infection and several functions were related to the antiviral mechanisms of silkworm.
American Psychological Association (APA)
Li, Gang& Qian, Heying& Luo, Xufang& Xu, Pingzhen& Yang, Jianhua& Liu, Mingzhu…[et al.]. 2016. Transcriptomic Analysis of Resistant and Susceptible Bombyx mori Strains Following BmNPV Infection Provides Insights into the Antiviral Mechanisms. International Journal of Genomics،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106140
Modern Language Association (MLA)
Li, Gang…[et al.]. Transcriptomic Analysis of Resistant and Susceptible Bombyx mori Strains Following BmNPV Infection Provides Insights into the Antiviral Mechanisms. International Journal of Genomics No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1106140
American Medical Association (AMA)
Li, Gang& Qian, Heying& Luo, Xufang& Xu, Pingzhen& Yang, Jianhua& Liu, Mingzhu…[et al.]. Transcriptomic Analysis of Resistant and Susceptible Bombyx mori Strains Following BmNPV Infection Provides Insights into the Antiviral Mechanisms. International Journal of Genomics. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106140