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Integration of HIV in the Human Genome: Which Sites Are Preferential? A Genetic and Statistical Assessment
Joint Authors
Gonçalves, Juliana
Moreira, Elsa
Sequeira, Inês J.
Rodrigues, António S.
Rueff, José
Brás, Aldina
Source
International Journal of Genomics
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Chromosomal fragile sites (FSs) are loci where gaps and breaks may occur and are preferential integration targets for some viruses, for example, Hepatitis B, Epstein-Barr virus, HPV16, HPV18, and MLV vectors.
However, the integration of the human immunodeficiency virus (HIV) in Giemsa bands and in FSs is not yet completely clear.
This study aimed to assess the integration preferences of HIV in FSs and in Giemsa bands using an in silico study.
HIV integration positions from Jurkat cells were used and two nonparametric tests were applied to compare HIV integration in dark versus light bands and in FS versus non-FS (NFSs).
The results show that light bands are preferential targets for integration of HIV-1 in Jurkat cells and also that it integrates with equal intensity in FSs and in NFSs.
The data indicates that HIV displays different preferences for FSs compared to other viruses.
The aim was to develop and apply an approach to predict the conditions and constraints of HIV insertion in the human genome which seems to adequately complement empirical data.
American Psychological Association (APA)
Gonçalves, Juliana& Moreira, Elsa& Sequeira, Inês J.& Rodrigues, António S.& Rueff, José& Brás, Aldina. 2016. Integration of HIV in the Human Genome: Which Sites Are Preferential? A Genetic and Statistical Assessment. International Journal of Genomics،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1106145
Modern Language Association (MLA)
Gonçalves, Juliana…[et al.]. Integration of HIV in the Human Genome: Which Sites Are Preferential? A Genetic and Statistical Assessment. International Journal of Genomics No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1106145
American Medical Association (AMA)
Gonçalves, Juliana& Moreira, Elsa& Sequeira, Inês J.& Rodrigues, António S.& Rueff, José& Brás, Aldina. Integration of HIV in the Human Genome: Which Sites Are Preferential? A Genetic and Statistical Assessment. International Journal of Genomics. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1106145
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106145