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Genetic Characterization and Comparative Genome Analysis of Brucella melitensis Isolates from India
Joint Authors
Gupta, Vivek Kumar
Azam, Sarwar
Rao, Sashi Bhushan
Jakka, Padmaja
NarasimhaRao, Veera
Bhargavi, Bindu
Radhakrishnan, Girish
Source
International Journal of Genomics
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Brucellosis is the most frequent zoonotic disease worldwide, with over 500,000 new human infections every year.
Brucella melitensis, the most virulent species in humans, primarily affects goats and the zoonotic transmission occurs by ingestion of unpasteurized milk products or through direct contact with fetal tissues.
Brucellosis is endemic in India but no information is available on population structure and genetic diversity of Brucella spp.
in India.
We performed multilocus sequence typing of four B.
melitensis strains isolated from naturally infected goats from India.
For more detailed genetic characterization, we carried out whole genome sequencing and comparative genome analysis of one of the B.
melitensis isolates, Bm IND1.
Genome analysis identified 141 unique SNPs, 78 VNTRs, 51 Indels, and 2 putative prophage integrations in the Bm IND1 genome.
Our data may help to develop improved epidemiological typing tools and efficient preventive strategies to control brucellosis.
American Psychological Association (APA)
Azam, Sarwar& Rao, Sashi Bhushan& Jakka, Padmaja& NarasimhaRao, Veera& Bhargavi, Bindu& Gupta, Vivek Kumar…[et al.]. 2016. Genetic Characterization and Comparative Genome Analysis of Brucella melitensis Isolates from India. International Journal of Genomics،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1106151
Modern Language Association (MLA)
Azam, Sarwar…[et al.]. Genetic Characterization and Comparative Genome Analysis of Brucella melitensis Isolates from India. International Journal of Genomics No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1106151
American Medical Association (AMA)
Azam, Sarwar& Rao, Sashi Bhushan& Jakka, Padmaja& NarasimhaRao, Veera& Bhargavi, Bindu& Gupta, Vivek Kumar…[et al.]. Genetic Characterization and Comparative Genome Analysis of Brucella melitensis Isolates from India. International Journal of Genomics. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1106151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106151