Profiling of the Predicted Circular RNAs in Ductal In Situ and Invasive Breast Cancer: A Pilot Study
Joint Authors
Galasso, Marco
Costantino, Giorgio
Pasquali, Lorenzo
Minotti, Linda
Baldassari, Federica
Corrà, Fabio
Agnoletto, Chiara
Volinia, Stefano
Source
International Journal of Genomics
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The recent advantage obtained by next generation sequencing allows a depth investigation of a new “old” kind of noncoding transcript, the circular RNAs.
Circular RNAs are nontranslated RNAs, typically nonpolyadenylated, with a resistance to exonucleases that gives them the ability to be more stable than the common linear RNA isoforms.
We used a bioinformatic detection tool (CIRCexplorer) to research predictive circRNAs from the next generation sequenced data of five samples of ductal in situ carcinoma (DCIS) and matched adjacent invasive ductal carcinoma (IDC).
Furthermore, we also investigated the circular RNAs expressed in MCF7, an invasive breast ductal carcinoma cell line.
We described the genomic context of the predicted circular RNAs and we address the hypothetical possible functional roles.
This study showed a perspective of a panel of predictive circRNAs identified and the function that circRNAs could exert.
American Psychological Association (APA)
Galasso, Marco& Costantino, Giorgio& Pasquali, Lorenzo& Minotti, Linda& Baldassari, Federica& Corrà, Fabio…[et al.]. 2016. Profiling of the Predicted Circular RNAs in Ductal In Situ and Invasive Breast Cancer: A Pilot Study. International Journal of Genomics،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1106160
Modern Language Association (MLA)
Galasso, Marco…[et al.]. Profiling of the Predicted Circular RNAs in Ductal In Situ and Invasive Breast Cancer: A Pilot Study. International Journal of Genomics No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1106160
American Medical Association (AMA)
Galasso, Marco& Costantino, Giorgio& Pasquali, Lorenzo& Minotti, Linda& Baldassari, Federica& Corrà, Fabio…[et al.]. Profiling of the Predicted Circular RNAs in Ductal In Situ and Invasive Breast Cancer: A Pilot Study. International Journal of Genomics. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1106160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106160