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Drug Target Identification and Prioritization for Treatment of Ovine Foot Rot: An In Silico Approach
Joint Authors
Acharya, Abhishek
Garg, Lalit C.
Source
International Journal of Genomics
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Ovine foot rot is an infection of the feet of sheep, mainly caused by Dichelobacter nodosus.
In its virulent form, it is highly contagious and debilitating, causing significant losses in the form of decline in wool growth and quality and poor fertility.
Current methods of treatment are ineffective in complete eradication.
Effective antibiotic treatment of foot rot is hence necessary to ensure better outcomes during control phases by reduction in culling count and the possibility of carriers of the infection.
Using computational approaches, we have identified a set of 297 proteins that are essential to the D.
nodosus and nonhomologous with sheep proteins.
These proteins may be considered as potential vaccine candidates or drug targets for designing antibiotics against the bacterium.
This core set of drug targets have been analyzed for pathway annotation to identify 67 proteins involved in unique bacterial pathways.
Choke-point analysis on the drug targets identified 138 choke-point proteins, 29 involved in unique bacterial pathways.
Subcellular localization was also predicted for each target to identify the ones that are membrane associated or secreted extracellularly.
In addition, a total of 13 targets were identified that are common in at least 10 pathogenic bacterial species.
American Psychological Association (APA)
Acharya, Abhishek& Garg, Lalit C.. 2016. Drug Target Identification and Prioritization for Treatment of Ovine Foot Rot: An In Silico Approach. International Journal of Genomics،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1106181
Modern Language Association (MLA)
Acharya, Abhishek& Garg, Lalit C.. Drug Target Identification and Prioritization for Treatment of Ovine Foot Rot: An In Silico Approach. International Journal of Genomics No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1106181
American Medical Association (AMA)
Acharya, Abhishek& Garg, Lalit C.. Drug Target Identification and Prioritization for Treatment of Ovine Foot Rot: An In Silico Approach. International Journal of Genomics. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1106181
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106181