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Cardiovascular Autonomic Dysfunction in Patients of Nonalcoholic Fatty Liver Disease
Joint Authors
Ramakrishnan, Lakshmy
Kumar, Mavidi Sunil
Singh, Akanksha
Jaryal, Ashok Kumar
Ranjan, Piyush
Deepak, K. K.
Sharma, Sanjay
Vikram, Naval
Pandey, R. M.
Source
International Journal of Hepatology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
The present study was designed to evaluate the heart rate variability (HRV) in nonalcoholic fatty liver disease (NAFLD) and to assess the effect of grade of NAFLD and diabetic status on HRV.
Methods.
This cross-sectional study included 75 subjects (25 NAFLD without diabetes, 25 NAFLD with diabetes, and 25 controls).
Measurements included anthropometry, body composition analysis, estimation of plasma glucose, serum lipids, hsCRP, and serum insulin.
HRV analysis was performed in both time and frequency domains.
Results.
The time and frequency domain indices of overall variability (SDNN, total power) were significantly lower in NAFLD with diabetes as compared to the controls.
However, the LF : HF ratio did not differ among the three groups.
The variables related to obesity, lipid profile, and glucose metabolism were also higher in NAFLD with diabetes and those with Grade II NAFLD without diabetes, as compared to controls.
Multivariate stepwise regression analysis showed a negative correlation between HRV and total cholesterol and fat percentage.
Conclusion.
The grade of NAFLD as well as diabetic status contributes to the decrease in the cardiovascular autonomic function, with diabetic status rather than grade of NAFLD playing a critical role.
Serum lipids and adiposity may also contribute to cardiac autonomic dysfunction.
American Psychological Association (APA)
Kumar, Mavidi Sunil& Singh, Akanksha& Jaryal, Ashok Kumar& Ranjan, Piyush& Deepak, K. K.& Sharma, Sanjay…[et al.]. 2016. Cardiovascular Autonomic Dysfunction in Patients of Nonalcoholic Fatty Liver Disease. International Journal of Hepatology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1106217
Modern Language Association (MLA)
Kumar, Mavidi Sunil…[et al.]. Cardiovascular Autonomic Dysfunction in Patients of Nonalcoholic Fatty Liver Disease. International Journal of Hepatology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1106217
American Medical Association (AMA)
Kumar, Mavidi Sunil& Singh, Akanksha& Jaryal, Ashok Kumar& Ranjan, Piyush& Deepak, K. K.& Sharma, Sanjay…[et al.]. Cardiovascular Autonomic Dysfunction in Patients of Nonalcoholic Fatty Liver Disease. International Journal of Hepatology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1106217
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106217