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Changes in Angiotensin Receptor Distribution and in Aortic Morphology Are Associated with Blood Pressure Control in Aged Metabolic Syndrome Rats
Joint Authors
Guarner Lans, Verónica
Carvajal, Karla
Rubio-Ruiz, María Esther
Soria-Castro, E.
Torrico-Lavayen, R.
Patrón-Soberano, Araceli
Castrejón-Tellez, Vicente
Source
International Journal of Hypertension
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The role of the renin-angiotensin system (RAS) in blood pressure regulation in MS during aging is unknown.
It participates in metabolic syndrome (MS) and aging regulating vascular tone and remodeling.
RAS might participate in a compensatory mechanism decreasing blood pressure and allowing MS rats to reach 18 months of age and it might form part of therapeutical procedures to ameliorate MS.
We studied histological changes and distribution of RAS receptors in aortas of MS aged rats.
Electron microscopy images showed premature aging in MS since the increased fibrosis, enlarged endothelium, and invasion of this layer by muscle cells that was present in control 18-month-old aortas were also found in 6-month-old aortas from MS rats.
AT1, AT2, and Mas receptors mediate the effects of Ang II and Ang 1-7, respectively.
Fluorescence from AT2 decreased with age in control and MS aortas, while fluorescence of AT1 increased in aortas from MS rats at 6 months and diminished during aging.
Mas expression increased in MS rats and remained unchanged in control rats.
In conclusion, there is premature aging in the aortas from MS rats and the elevated expression of Mas receptor might contribute to decrease blood pressure during aging in MS.
American Psychological Association (APA)
Guarner Lans, Verónica& Soria-Castro, E.& Torrico-Lavayen, R.& Patrón-Soberano, Araceli& Carvajal, Karla& Castrejón-Tellez, Vicente…[et al.]. 2016. Changes in Angiotensin Receptor Distribution and in Aortic Morphology Are Associated with Blood Pressure Control in Aged Metabolic Syndrome Rats. International Journal of Hypertension،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1106237
Modern Language Association (MLA)
Guarner Lans, Verónica…[et al.]. Changes in Angiotensin Receptor Distribution and in Aortic Morphology Are Associated with Blood Pressure Control in Aged Metabolic Syndrome Rats. International Journal of Hypertension No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1106237
American Medical Association (AMA)
Guarner Lans, Verónica& Soria-Castro, E.& Torrico-Lavayen, R.& Patrón-Soberano, Araceli& Carvajal, Karla& Castrejón-Tellez, Vicente…[et al.]. Changes in Angiotensin Receptor Distribution and in Aortic Morphology Are Associated with Blood Pressure Control in Aged Metabolic Syndrome Rats. International Journal of Hypertension. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1106237
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106237