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The Role of Renal Replacement Therapy in the Management of Pharmacologic Poisonings
Joint Authors
Mirrakhimov, Aibek E.
Gray, Adam
Ayach, Taha
Barbaryan, Aram
Source
International Journal of Nephrology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Pharmacologic toxicities are common and range from mild to life-threatening.
The aim of this study is to review and update the data on the role of renal replacement therapy (RRT) in the management of various pharmacologic poisonings.
We aim to provide a focused review on the role of RRT in the management of pharmacological toxicities.
Relevant publications were searched in MEDLINE with the following search terms alone or in combination: pharmacologic toxicity, hemodialysis, hemofiltration, renal replacement therapy, toxicology, poisonings, critical illness, and intensive care.
The studies showed that a pharmacologic substance should meet several prerequisites to be deemed dialyzable.
These variables include having a low molecular weight (<500 Da) and low degree of protein binding (<80%), being water-soluble, and having a low volume of distribution (<1 L/kg).
RRT should be strongly considered in critically ill patients presenting with toxic alcohol ingestion, salicylate overdose, severe valproic acid toxicity, metformin overdose, and lithium poisoning.
The role of RRT in other pharmacologic toxicities is less certain and should be considered on a case-by-case basis.
American Psychological Association (APA)
Mirrakhimov, Aibek E.& Barbaryan, Aram& Gray, Adam& Ayach, Taha. 2016. The Role of Renal Replacement Therapy in the Management of Pharmacologic Poisonings. International Journal of Nephrology،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1106343
Modern Language Association (MLA)
Mirrakhimov, Aibek E.…[et al.]. The Role of Renal Replacement Therapy in the Management of Pharmacologic Poisonings. International Journal of Nephrology No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1106343
American Medical Association (AMA)
Mirrakhimov, Aibek E.& Barbaryan, Aram& Gray, Adam& Ayach, Taha. The Role of Renal Replacement Therapy in the Management of Pharmacologic Poisonings. International Journal of Nephrology. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1106343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106343