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Urinary Markers of Tubular Injury in Early Diabetic Nephropathy
Joint Authors
Source
International Journal of Nephrology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is a common and serious complication of diabetes associated with adverse outcomes of renal failure, cardiovascular disease, and premature mortality.
Early and accurate identification of DN is therefore of critical importance to improve patient outcomes.
Albuminuria, a marker of glomerular involvement in early renal damage, cannot always detect early DN.
Thus, more sensitive and specific markers in addition to albuminuria are needed to predict the early onset and progression of DN.
Tubular injury, as shown by the detection of tubular injury markers in the urine, is a critical component of the early course of DN.
These urinary tubular markers may increase in diabetic patients, even before diagnosis of microalbuminuria representing early markers of normoalbuminuric DN.
In this review we summarized some new and important urinary markers of tubular injury, such as neutrophil gelatinase associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), liver-type fatty acid binding protein (L-FABP), N-acetyl-beta-glucosaminidase (NAG), alpha-1 microglobulin (A1M), beta 2-microglobulin (B2-M), and retinol binding protein (RBP) associated with early DN.
American Psychological Association (APA)
Fiseha, Temesgen& Tamir, Zemenu. 2016. Urinary Markers of Tubular Injury in Early Diabetic Nephropathy. International Journal of Nephrology،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106346
Modern Language Association (MLA)
Fiseha, Temesgen& Tamir, Zemenu. Urinary Markers of Tubular Injury in Early Diabetic Nephropathy. International Journal of Nephrology No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1106346
American Medical Association (AMA)
Fiseha, Temesgen& Tamir, Zemenu. Urinary Markers of Tubular Injury in Early Diabetic Nephropathy. International Journal of Nephrology. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106346
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106346