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Prevalence and Risk Factors of Lower Limb Amputation in Patients with End-Stage Renal Failure on Dialysis: A Systematic Review
Joint Authors
Gilhotra, Rajit A.
Rodrigues, Beverly T.
Vangaveti, Venkat N.
Malabu, Usman H.
Source
International Journal of Nephrology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Renal dialysis has recently been recognised as a risk factor for lower limb amputation (LLA).
However, exact rates and associated risk factors for the LLA are incompletely understood.
Aim.
Prevalence and risk factors of LLA in end-stage renal failure (ESRF) subjects on renal dialysis were investigated from the existing literature.
Methods.
Published data on the subject were derived from MEDLINE, PubMed, and Google Scholar search of English language literature from January 1, 1980, to July 31, 2015, using designated key words.
Results.
Seventy studies were identified out of which 6 full-text published studies were included in this systematic review of which 5 included patients on haemodialysis alone and one included patients on both haemodialysis and peritoneal dialysis.
The reported findings on prevalence of amputation in the renal failure on dialysis cohort ranged from 1.7% to 13.4%.
Five out of the six studies identified diabetes as the leading risk factor for amputation in subjects with ESRF on renal dialysis.
Other risk factors identified were high haemoglobin A1c, elevated c-reactive protein, and low serum albumin.
Conclusions.
This review demonstrates high rate of LLA in ESRF patients receiving dialysis therapy.
It has also identified diabetes and markers of inflammation as risk factors of amputation in ESRF subjects on dialysis.
American Psychological Association (APA)
Gilhotra, Rajit A.& Rodrigues, Beverly T.& Vangaveti, Venkat N.& Malabu, Usman H.. 2016. Prevalence and Risk Factors of Lower Limb Amputation in Patients with End-Stage Renal Failure on Dialysis: A Systematic Review. International Journal of Nephrology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1106347
Modern Language Association (MLA)
Gilhotra, Rajit A.…[et al.]. Prevalence and Risk Factors of Lower Limb Amputation in Patients with End-Stage Renal Failure on Dialysis: A Systematic Review. International Journal of Nephrology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1106347
American Medical Association (AMA)
Gilhotra, Rajit A.& Rodrigues, Beverly T.& Vangaveti, Venkat N.& Malabu, Usman H.. Prevalence and Risk Factors of Lower Limb Amputation in Patients with End-Stage Renal Failure on Dialysis: A Systematic Review. International Journal of Nephrology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1106347
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106347