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Effects of Therapy on Urine Neutrophil Gelatinase-Associated Lipocalin in Nondiabetic Glomerular Diseases with Proteinuria
Joint Authors
Thakkinstian, Ammarin
Phakdeekitcharoen, Bunyong
Sirisopha, Amnuay
Vanavanan, Somlak
Chittamma, Anchalee
Lertrit, Amornpan
Sathirapongsasuti, Nuankanya
Kitiyakara, Chagriya
Source
International Journal of Nephrology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Urine neutrophil gelatinase-associated lipocalin (NGAL) is widely used as a biomarker for acute kidney injury.
Cross-sectional studies have shown that NGAL may be elevated in glomerular diseases, but there is limited information on the value of NGAL in predicting treatment response or on the changes of NGAL levels after therapy.
We prospectively evaluated the effects of therapy on NGAL in nondiabetic glomerular diseases.
Urine NGAL was collected at biopsy and follow-up at 12 months.
At baseline, NGAL in glomerular disease patients ( n = 43 ) correlated with proteinuria, but not with glomerular filtration rate (GFR).
After therapy with renin-angiotensin blockers and/or immune modulating agents, change of NGAL correlated with change of proteinuria, but not with change of GFR.
NGAL at baseline was not different between patients in complete remission (CR) at follow-up compared to those not in remission (NR).
Compared to baseline, NGAL at follow-up decreased in CR ( n = 10 ), but not in NR.
Change of NGAL was greater in CR than NR.
In conclusion, the change of urine NGAL correlated with the change of proteinuria.
Baseline NGAL was not a predictor of complete remission.
Future studies will be necessary to determine the role of NGAL as a predictor of long term outcome in proteinuric glomerular diseases.
American Psychological Association (APA)
Sirisopha, Amnuay& Vanavanan, Somlak& Chittamma, Anchalee& Phakdeekitcharoen, Bunyong& Thakkinstian, Ammarin& Lertrit, Amornpan…[et al.]. 2016. Effects of Therapy on Urine Neutrophil Gelatinase-Associated Lipocalin in Nondiabetic Glomerular Diseases with Proteinuria. International Journal of Nephrology،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1106348
Modern Language Association (MLA)
Sirisopha, Amnuay…[et al.]. Effects of Therapy on Urine Neutrophil Gelatinase-Associated Lipocalin in Nondiabetic Glomerular Diseases with Proteinuria. International Journal of Nephrology No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1106348
American Medical Association (AMA)
Sirisopha, Amnuay& Vanavanan, Somlak& Chittamma, Anchalee& Phakdeekitcharoen, Bunyong& Thakkinstian, Ammarin& Lertrit, Amornpan…[et al.]. Effects of Therapy on Urine Neutrophil Gelatinase-Associated Lipocalin in Nondiabetic Glomerular Diseases with Proteinuria. International Journal of Nephrology. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1106348
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106348