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Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with Diabetes
Joint Authors
Losito, Attilio
Pittavini, Loretta
Zampi, Ivano
Zampi, Elena
Source
International Journal of Nephrology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We aimed at comparing the relationship of reduced estimated glomerular filtration rate (eGFR) with cardiovascular disease (CVD) and mortality between high risk patients with and without type 2 diabetes mellitus (T2DM).
The cross-sectional study evaluated 16,298 participants (1,627 T2DM) acutely admitted to hospital.
The longitudinal study comprised 7,508 patients (673 with diabetes and 6,835 without).
eGFR was categorized into 6 stages from >90 to <15 mL/min/1.73 m2.
Kidney dysfunction was defined by an eGFR < 60 mL/min/1.73 m2.
Patients with T2D showed a higher prevalence of CVD (37.9% versus 23.6%; P<0.001) and kidney dysfunction (25% versus 13.2%; P<0.001) than in the general population.
An association with CVD was found with eGFR stages from 30 to 90 mL/min/1.73 m2 in T2D and from <15 to 90 mL/min/1.73 m2 in general population, in whom the association of eGFR with coronary heart disease was in an inverse relationship (P<0.01 for trend).
Survival, in diabetes, was lower (P=0.037) but not associated with kidney dysfunction.
Conclusions.
In a high risk population, patients admitted to hospital, the relationship of kidney function with CVD is different between T2D and the general population.
Competing mortality and the presence of other major risk factors in diabetes may be responsible for this difference.
American Psychological Association (APA)
Losito, Attilio& Pittavini, Loretta& Zampi, Ivano& Zampi, Elena. 2016. Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with Diabetes. International Journal of Nephrology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1106355
Modern Language Association (MLA)
Losito, Attilio…[et al.]. Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with Diabetes. International Journal of Nephrology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1106355
American Medical Association (AMA)
Losito, Attilio& Pittavini, Loretta& Zampi, Ivano& Zampi, Elena. Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with Diabetes. International Journal of Nephrology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1106355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106355