Efficacy of 670 nm Light Therapy to Protect against Photoreceptor Cell Death Is Dependent on the Severity of Damage
Joint Authors
Chu-Tan, Joshua A.
Rutar, Matt
Saxena, Kartik
Wu, Yunlu
Howitt, Lauren
Valter, Krisztina
Provis, Jan
Natoli, Riccardo
Source
International Journal of Photoenergy
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Photobiomodulation at a wavelength of 670 nm has been shown to be effective in preventing photoreceptor cell death in the retina.
We treated Sprague-Dawley (SD) rats with varying doses of 670 nm light (9; 18; 36; 90 J/cm2) before exposing them to different intensities of damaging white light (750; 1000; 1500 lux).
670 nm light exhibited a biphasic response in its amelioration of cell death in light-induced degeneration in vivo.
Lower light damage intensities required lower doses of 670 nm light to reduce TUNEL cell death.
At higher damage intensities, the highest dose of 670 nm light showed protection.
In vitro, the Seahorse XFe96 Extracellular Flux Analyzer revealed that 670 nm light directly influences mitochondrial metabolism by increasing the spare respiratory capacity of mitochondria in 661 W photoreceptor-like cells in light damaged conditions.
Our findings further support the use of 670 nm light as an effective treatment against retinal degeneration as well as shedding light on the mechanism of protection through the increase of the mitochondrial spare respiratory capacity.
American Psychological Association (APA)
Chu-Tan, Joshua A.& Rutar, Matt& Saxena, Kartik& Wu, Yunlu& Howitt, Lauren& Valter, Krisztina…[et al.]. 2016. Efficacy of 670 nm Light Therapy to Protect against Photoreceptor Cell Death Is Dependent on the Severity of Damage. International Journal of Photoenergy،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1106446
Modern Language Association (MLA)
Chu-Tan, Joshua A.…[et al.]. Efficacy of 670 nm Light Therapy to Protect against Photoreceptor Cell Death Is Dependent on the Severity of Damage. International Journal of Photoenergy No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1106446
American Medical Association (AMA)
Chu-Tan, Joshua A.& Rutar, Matt& Saxena, Kartik& Wu, Yunlu& Howitt, Lauren& Valter, Krisztina…[et al.]. Efficacy of 670 nm Light Therapy to Protect against Photoreceptor Cell Death Is Dependent on the Severity of Damage. International Journal of Photoenergy. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1106446
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106446