Combinational Effect of Cell Adhesion Biomolecules and Their Immobilized Polymer Property to Enhance Cell-Selective Adhesion
Joint Authors
Idota, Naokazu
Kurimoto, Rio
Kanie, Kei
Hara, Mitsuo
Nagano, Shusaku
Tsukahara, Takehiko
Narita, Yuji
Naito, Masanobu
Ebara, Mitsuhiro
Kato, Ryuji
Honda, Hiroyuki
Source
International Journal of Polymer Science
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Although surface immobilization of medical devices with bioactive molecules is one of the most widely used strategies to improve biocompatibility, the physicochemical properties of the biomaterials significantly impact the activity of the immobilized molecules.
Herein we investigate the combinational effects of cell-selective biomolecules and the hydrophobicity/hydrophilicity of the polymeric substrate on selective adhesion of endothelial cells (ECs), fibroblasts (FBs), and smooth muscle cells (SMCs).
To control the polymeric substrate, biomolecules are immobilized on thermoresponsive poly(N-isopropylacrylamide-co-2-carboxyisopropylacrylamide) (poly(NIPAAm-co-CIPAAm))-grafted glass surfaces.
By switching the molecular conformation of the biomolecule-immobilized polymers, the cell-selective adhesion performances are evaluated.
In case of RGDS (Arg-Gly-Asp-Ser) peptide-immobilized surfaces, all cell types adhere well regardless of the surface hydrophobicity.
On the other hand, a tri-Arg-immobilized surface exhibits FB-selectivity when the surface is hydrophilic.
Additionally, a tri-Ile-immobilized surface exhibits EC-selective cell adhesion when the surface is hydrophobic.
We believe that the proposed concept, which is used to investigate the biomolecule-immobilized surface combination, is important to produce new biomaterials, which are highly demanded for medical implants and tissue engineering.
American Psychological Association (APA)
Kurimoto, Rio& Kanie, Kei& Idota, Naokazu& Hara, Mitsuo& Nagano, Shusaku& Tsukahara, Takehiko…[et al.]. 2016. Combinational Effect of Cell Adhesion Biomolecules and Their Immobilized Polymer Property to Enhance Cell-Selective Adhesion. International Journal of Polymer Science،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1106639
Modern Language Association (MLA)
Kurimoto, Rio…[et al.]. Combinational Effect of Cell Adhesion Biomolecules and Their Immobilized Polymer Property to Enhance Cell-Selective Adhesion. International Journal of Polymer Science No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1106639
American Medical Association (AMA)
Kurimoto, Rio& Kanie, Kei& Idota, Naokazu& Hara, Mitsuo& Nagano, Shusaku& Tsukahara, Takehiko…[et al.]. Combinational Effect of Cell Adhesion Biomolecules and Their Immobilized Polymer Property to Enhance Cell-Selective Adhesion. International Journal of Polymer Science. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1106639
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106639