Deposition of Ibuprofen Crystals on Hydroxypropyl CellulosePolyacrylamide Gel: Experimental and Mathematic Modeling Releasing
Joint Authors
Morales-Cepeda, A. B.
Castillo-Miranda, Claudia Alicia
Castro-Guerrero, Carlos Fernando
Salas-Papayanopolos, Homero
Velasco-Ocejo, Hugo Alberto
González-Sánchez, Jorge Alberto
Paramo-Garcia, Ulises
De Alva-Salazar, Hugo
Source
International Journal of Polymer Science
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The crystallization of nonsteroidal anti-inflammatory drug [2-(4-isobutyl-phenyl) propionic acid] ibuprofen (IBP) on a hydroxypropyl cellulose (HPC) and polyacrylamide (PAAm) gel was studied as well as the release kinetics of the drug.
The IBP was crystallized on the gel surface of HPC/PAAm.
It had a prismatic shape and the growth was made in an aqueous medium; the crystallinity grade of the gels HPC/PAAm and HPC/PAAm-IBU increased to 68% and to 58%, respectively.
The release of IBP is performed by two means: by a non-Fickian diffusion process and by relaxation of the chains of the gel; without regard to temperature and the diffusion media, this correlates with the lower critical solution temperature (LCST) of the proposed gel.
This polymer matrix provides an option for releasing nonsteroidal anti-inflammatory drugs in a temperature range of 35–39°C.
Korsmeyer and Peppas mathematical model was simulated for data releases, statistically significant at 95% confidence level.
American Psychological Association (APA)
Castillo-Miranda, Claudia Alicia& Morales-Cepeda, A. B.& Castro-Guerrero, Carlos Fernando& Salas-Papayanopolos, Homero& Velasco-Ocejo, Hugo Alberto& González-Sánchez, Jorge Alberto…[et al.]. 2016. Deposition of Ibuprofen Crystals on Hydroxypropyl CellulosePolyacrylamide Gel: Experimental and Mathematic Modeling Releasing. International Journal of Polymer Science،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1106661
Modern Language Association (MLA)
Castillo-Miranda, Claudia Alicia…[et al.]. Deposition of Ibuprofen Crystals on Hydroxypropyl CellulosePolyacrylamide Gel: Experimental and Mathematic Modeling Releasing. International Journal of Polymer Science No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1106661
American Medical Association (AMA)
Castillo-Miranda, Claudia Alicia& Morales-Cepeda, A. B.& Castro-Guerrero, Carlos Fernando& Salas-Papayanopolos, Homero& Velasco-Ocejo, Hugo Alberto& González-Sánchez, Jorge Alberto…[et al.]. Deposition of Ibuprofen Crystals on Hydroxypropyl CellulosePolyacrylamide Gel: Experimental and Mathematic Modeling Releasing. International Journal of Polymer Science. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1106661
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106661