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Biocompatible and Biodegradable Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Prepared via Semicontinuous Heterophase Polymerization: Kinetics and Product Characterization
Joint Authors
Ilyna, Anna
Enríquez-Medrano, Francisco Javier
Saade, Hened
López, Raúl G.
Guillén, María de Lourdes
Romero, Judith Cabello
Cepeda, Jesús
Fernández, Salvador
Source
International Journal of Polymer Science
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Ultrafine nanoparticles, less than 10 nm in mean diameter, of the FDA approved copolymer methyl methacrylate- (MMA-) co-methacrylic acid (MAA), 2/1 (mol/mol), were prepared.
The method used for the preparation of these particles stabilized in a latex containing around 11% solids includes the dosing of the monomers mixture on a micellar solution preserving monomer starved conditions.
It is thought that the operation at these conditions combined with the hydrophilicity of MMA and MAA units favors the formation of ultrafine particles; the propagation reaction carried out within so small compartments renders copolymer chains rich in syndiotactic units very likely as consequence of the restricted movements of the end propagation of the chains.
Because of their biocompatibility and biodegradability as well as their extremely small size these nanoparticles could be used as vehicles for improved drug delivery in the treatment of chronic-degenerative diseases.
American Psychological Association (APA)
Saade, Hened& Guillén, María de Lourdes& Romero, Judith Cabello& Cepeda, Jesús& Ilyna, Anna& Fernández, Salvador…[et al.]. 2016. Biocompatible and Biodegradable Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Prepared via Semicontinuous Heterophase Polymerization: Kinetics and Product Characterization. International Journal of Polymer Science،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1106851
Modern Language Association (MLA)
Saade, Hened…[et al.]. Biocompatible and Biodegradable Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Prepared via Semicontinuous Heterophase Polymerization: Kinetics and Product Characterization. International Journal of Polymer Science No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1106851
American Medical Association (AMA)
Saade, Hened& Guillén, María de Lourdes& Romero, Judith Cabello& Cepeda, Jesús& Ilyna, Anna& Fernández, Salvador…[et al.]. Biocompatible and Biodegradable Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Prepared via Semicontinuous Heterophase Polymerization: Kinetics and Product Characterization. International Journal of Polymer Science. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1106851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106851