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Synthesis of Functional Polyester Based on Polylactic Acid and Its Effect on PC12 Cells after Coupling with Small Peptides
Joint Authors
Qiang, Na
Tang, Shuo
Liao, Xiang
Liang, Hao
Xie, Fang
Zhu, Ji-xiang
Source
International Journal of Polymer Science
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Polyesters containing functional groups are a suitable candidate matrix for cell culture in tissue engineering.
Three types of semicrystalline copolymer poly(l-lactide-co-β-malic acid) [P(LA-co-BMD)] with pendent carboxyl groups were synthesized in this study.
The functional monomer 3(S)-[(benzyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione (BMD) was synthesized using l-aspartic acid.
The copolymer P(LA-co-BMD) was then synthesized through ring-opening copolymerization of l-LA and BMD, with dodecanol as initiator and stannous octoate as catalyst.
Copolymer structure was characterized by 1H nuclear magnetic resonance (1H NMR), gel permeation chromatography (GPC), and differential scanning calorimetry (DSC) analyses.
Results of 1H NMR and GPC analyses showed that the copolymers were synthesized successfully.
DSC curves showed that the crystal melting peak and enthalpy decreased with increased BMD.
The crystallinity of the copolymer was destroyed by the presence of the functional monomer.
After deprotection, carboxyl groups were coupled with the isoleucine-lysine-valine-alanine-valine peptide through N-hydroxysuccinimide/dicyclohexylcarbodiimide method.
The small peptide was beneficial to the axon growth of PC12 cells.
American Psychological Association (APA)
Qiang, Na& Tang, Shuo& Liao, Xiang& Liang, Hao& Xie, Fang& Zhu, Ji-xiang. 2016. Synthesis of Functional Polyester Based on Polylactic Acid and Its Effect on PC12 Cells after Coupling with Small Peptides. International Journal of Polymer Science،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1106898
Modern Language Association (MLA)
Qiang, Na…[et al.]. Synthesis of Functional Polyester Based on Polylactic Acid and Its Effect on PC12 Cells after Coupling with Small Peptides. International Journal of Polymer Science No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1106898
American Medical Association (AMA)
Qiang, Na& Tang, Shuo& Liao, Xiang& Liang, Hao& Xie, Fang& Zhu, Ji-xiang. Synthesis of Functional Polyester Based on Polylactic Acid and Its Effect on PC12 Cells after Coupling with Small Peptides. International Journal of Polymer Science. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1106898
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106898