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Serum Amyloid A Level in Egyptian Children with Familial Mediterranean Fever
Joint Authors
Rashed, Laila
Marzouk, Huda
Lotfy, Hala M.
El-Garf, Kamal
Farag, Yomna
Nabih, Mohammad
Khalifa, Iman A. S.
Mostafa, Noha
Salah, Ahmed
Source
International Journal of Rheumatology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background and Objectives.
SAA is an acute-phase reactant detected during an FMF attack or other inflammatory conditions.
High SAA levels may increase the risk of amyloidosis.
The aim of the study is to measure the serum amyloid A (SAA) level in a group of Egyptian children with familial Mediterranean fever (FMF) and study its various correlates, if any.
Methods.
The study enrolled seventy-one children with FMF.
Results.
SAA level was high in 78.9% of the studied patients with a mean of 81.62±31.6 mg/L, and CRP was positive in 31% of patients.
There was no significant releation between SAA level and any demographic or clinical manifestation.
High SAA was more frequent in V726A allele (16.9%) followed by M694V allele (12.3%).
Elevated SAA levels were more frequent in patients on low colchicine doses.
Forty-five percent (45%) of patients have low adherence to colchicine therapy.
Interpretation and Conclusion.
High SAA levels were detected two weeks after last FMF attack in a large percentage of Egyptian FMF children.
This indicates that subclinical inflammation continues during attack-free periods, and SAA could be used as a marker of it.
American Psychological Association (APA)
Lotfy, Hala M.& Marzouk, Huda& Farag, Yomna& Nabih, Mohammad& Khalifa, Iman A. S.& Mostafa, Noha…[et al.]. 2016. Serum Amyloid A Level in Egyptian Children with Familial Mediterranean Fever. International Journal of Rheumatology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1106912
Modern Language Association (MLA)
Lotfy, Hala M.…[et al.]. Serum Amyloid A Level in Egyptian Children with Familial Mediterranean Fever. International Journal of Rheumatology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1106912
American Medical Association (AMA)
Lotfy, Hala M.& Marzouk, Huda& Farag, Yomna& Nabih, Mohammad& Khalifa, Iman A. S.& Mostafa, Noha…[et al.]. Serum Amyloid A Level in Egyptian Children with Familial Mediterranean Fever. International Journal of Rheumatology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1106912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106912