Immune Mediators in Osteoarthritis: Infrapatellar Fat Pad-Infiltrating CD8+ T Cells Are Increased in Osteoarthritic Patients with Higher Clinical Radiographic Grading

Abstract EN

Osteoarthritis is a condition of joint failure characterized by many pathologic changes of joint-surrounding tissues.

Many evidences suggest the role of both innate and adaptive immunity that interplay, resulting either in initiation or in progression of osteoarthritis.

Adaptive immune cells, in particular T cells, have been demonstrated to play a role in the development of OA in animal models.

However, the underlying mechanism is yet unclear.

Our aim was to correlate the frequency and phenotype of tissue-infiltrating T cells in the synovial tissue and infrapatellar fat pad with radiographic grading.

Our results show that CD8+ T cells are increased in osteoarthritic patients with higher radiographic grading.

When peripheral blood CD8+ T cells were examined, we show that CD8+ T cells possess a significantly higher level of activation than its CD4+ T cell counterpart (P<0.0001).

Our results suggest a role for CD8+ T cells and recruitment of these activated circulating peripheral blood CD8+ T cells to the knee triggering local inflammation within the knee joint.