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Prognostic Relevance of the Peritoneal Surface Disease Severity Score Compared to the Peritoneal Cancer Index for Colorectal Peritoneal Carcinomatosis
Joint Authors
Ng, Jia Lin
Ong, Whee Sze
Chia, Claramae Shulyn
Tan, Grace Hwei Ching
Soo, Khee-Chee
Teo, Melissa Ching Ching
Source
International Journal of Surgical Oncology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Peritoneal Carcinomatosis Index (PCI) is a widely established scoring system that describes disease burden in isolated colorectal peritoneal carcinomatosis (CPC).
Its significance may be diminished with complete cytoreduction.
We explore the utility of the recently described Peritoneal Surface Disease Severity Score (PSDSS) and compare its prognostic value against PCI.
Methods.
The endpoints were overall survival (OS), progression-free survival (PFS), and survival less than 18 months (18 MS).
Results.
Fifty patients underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) for CPC from 2003 to 2014, with 98% achieving complete cytoreduction.
Median OS was 28.8 months (95% CI, 18.0–39.1); median PFS was 9.4 months (95% CI, 7.7–13.9).
Univariate analysis showed that higher PCI was significantly associated with poorer OS (HR 1.11; 95% CI, 1.03–1.20) and PFS (HR 1.09; 95% CI, 1.03–1.14).
Conversely, PSDSS was not associated with either endpoint.
Multivariate analysis showed that PCI, but not PSDSS, was predictive of OS and PFS.
PCI was also able to discriminate survival outcomes better than PSDSS for both OS and PFS.
There was no association between 18 MS and either score.
Conclusion.
PCI is superior to PSDSS in predicting OS and PFS and remains the prognostic score of choice in CPC patients undergoing CRS/HIPEC.
American Psychological Association (APA)
Ng, Jia Lin& Ong, Whee Sze& Chia, Claramae Shulyn& Tan, Grace Hwei Ching& Soo, Khee-Chee& Teo, Melissa Ching Ching. 2016. Prognostic Relevance of the Peritoneal Surface Disease Severity Score Compared to the Peritoneal Cancer Index for Colorectal Peritoneal Carcinomatosis. International Journal of Surgical Oncology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107073
Modern Language Association (MLA)
Ng, Jia Lin…[et al.]. Prognostic Relevance of the Peritoneal Surface Disease Severity Score Compared to the Peritoneal Cancer Index for Colorectal Peritoneal Carcinomatosis. International Journal of Surgical Oncology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1107073
American Medical Association (AMA)
Ng, Jia Lin& Ong, Whee Sze& Chia, Claramae Shulyn& Tan, Grace Hwei Ching& Soo, Khee-Chee& Teo, Melissa Ching Ching. Prognostic Relevance of the Peritoneal Surface Disease Severity Score Compared to the Peritoneal Cancer Index for Colorectal Peritoneal Carcinomatosis. International Journal of Surgical Oncology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107073
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107073