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Neoadjuvant Therapy in Differentiated Thyroid Cancer
Joint Authors
Dang, Rajan P.
McFarland, Daniel
Le, Valerie H.
Camille, Nadia
Misiukiewicz, Krzysztof J.
Miles, Brett
Teng, Marita S.
Genden, Eric M.
Source
International Journal of Surgical Oncology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
Invasion of differentiated thyroid cancer (DTC) into surrounding structures can lead to morbid procedures such as laryngectomy and tracheal resection.
In these patients, there is a potential role for neoadjuvant therapy.
Methods.
We identified three studies involving the treatment of DTC with neoadjuvant chemotherapy: two from Slovenia and one from Japan.
Results.
These studies demonstrate that in selected situations, neoadjuvant chemotherapy can have a good response and allow for a more complete surgical resection, the treatment of DTC.
Additionally, the SELECT trial shows that the targeted therapy lenvatinib is effective in the treatment of DTC and could be useful as neoadjuvant therapy for this disease due to its short time to response.
Pazopanib has also demonstrated promise in phase II data.
Conclusions.
Thus, chemotherapy in the neoadjuvant setting could possibly be useful for managing advanced DTC.
Additionally, some of the new tyrosine kinase inhibitors (TKIs) hold promise for use in the neoadjuvant setting in DTC.
American Psychological Association (APA)
Dang, Rajan P.& McFarland, Daniel& Le, Valerie H.& Camille, Nadia& Miles, Brett& Teng, Marita S.…[et al.]. 2016. Neoadjuvant Therapy in Differentiated Thyroid Cancer. International Journal of Surgical Oncology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1107075
Modern Language Association (MLA)
Dang, Rajan P.…[et al.]. Neoadjuvant Therapy in Differentiated Thyroid Cancer. International Journal of Surgical Oncology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1107075
American Medical Association (AMA)
Dang, Rajan P.& McFarland, Daniel& Le, Valerie H.& Camille, Nadia& Miles, Brett& Teng, Marita S.…[et al.]. Neoadjuvant Therapy in Differentiated Thyroid Cancer. International Journal of Surgical Oncology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1107075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107075