Preoperative Radiation Therapy Followed by Reexcision May Improve Local Control and Progression-Free Survival in Unplanned Excisions of Soft Tissue Sarcomas of the Extremity and Chest-Wall

Joint Authors

Bedi, Meena
Saeed, Hina
Johnstone, Candice A.
Charlson, John A.
Hackbarth, Donald A.
Neilson, John C.
King, David

Source

International Journal of Surgical Oncology

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-10-10

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases
Medicine

Abstract EN

Background.

The management for unplanned excision (UE) of soft tissue sarcomas (STS) has not been established.

In this study, we compare outcomes of UE versus planned excision (PE) and determine an optimal treatment for UE in STS.

Methods.

From 2000 to 2014 a review was performed on all patients treated with localized STS.

Clinical outcomes including local recurrence-free survival (LRFS), progression-free survival (PFS), and overall survival (OS) were evaluated using the Kaplan-Meier estimate.

Univariate (UVA) and multivariate (MVA) analyses were performed to determine prognostic variables.

For MVA, Cox proportional hazards model was used.

Results.

245 patients were included in the analysis.

14% underwent UE.

Median follow-up was 2.8 years.

The LR rate was 8.6%.

The LR rate in UE was 35% versus 4.2% in PE patients (p<0.0001).

2-year PFS in UE versus PE patients was 4.2 years and 9.3 years, respectively (p=0.08).

Preoperative radiation (RT) (p=0.01) and use of any RT for UE (p=0.003) led to improved PFS.

On MVA, preoperative RT (p=0.04) and performance status (p=0.01) led to improved PFS.

Conclusions.

UEs led to decreased LC and PFS versus PE in patients with STS.

The use of preoperative RT followed by reexcision improved LC and PFS in patients who had UE of their STS.

American Psychological Association (APA)

Saeed, Hina& King, David& Johnstone, Candice A.& Charlson, John A.& Hackbarth, Donald A.& Neilson, John C.…[et al.]. 2016. Preoperative Radiation Therapy Followed by Reexcision May Improve Local Control and Progression-Free Survival in Unplanned Excisions of Soft Tissue Sarcomas of the Extremity and Chest-Wall. International Journal of Surgical Oncology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1107077

Modern Language Association (MLA)

Saeed, Hina…[et al.]. Preoperative Radiation Therapy Followed by Reexcision May Improve Local Control and Progression-Free Survival in Unplanned Excisions of Soft Tissue Sarcomas of the Extremity and Chest-Wall. International Journal of Surgical Oncology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1107077

American Medical Association (AMA)

Saeed, Hina& King, David& Johnstone, Candice A.& Charlson, John A.& Hackbarth, Donald A.& Neilson, John C.…[et al.]. Preoperative Radiation Therapy Followed by Reexcision May Improve Local Control and Progression-Free Survival in Unplanned Excisions of Soft Tissue Sarcomas of the Extremity and Chest-Wall. International Journal of Surgical Oncology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1107077

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1107077