The Role of [18F]FDG-PETCT in Predicting Malignant Transformation of Plexiform Neurofibromas in Neurofibromatosis-1
Joint Authors
Tovmassian, David
Abdul Razak, Muzib
London, Kevin
Source
International Journal of Surgical Oncology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Malignant peripheral nerve sheath tumours (MPNSTs) are difficult to diagnose and treat and contribute to significant morbidity and mortality for patients with Neurofibromatosis-1 (NF-1).
FDG-PET/CT is being increasingly used as an imaging modality to discriminate between benign and malignant plexiform neurofibromas.
Objectives.
To assess the value of FDG-PET/CT in differentiating between benign and malignant peripheral nerve lesions for patients with Neurofibromatosis-1.
Methods.
A systematic review of the literature was performed prior to application of stringent selection criteria.
Ultimately 13 articles with 796 tumours were deemed eligible for inclusion into the review.
Results.
There was a significant difference between mean SUVmax of benign and malignant lesions (1.93 versus 7.48, resp.).
Sensitivity ranged from 89 to 100% and specificity from 72 to 94%.
ROC analysis was performed to maximise sensitivity and specificity of SUVmax cut-off; however no clear value was identified (range 3.1–6.1).
Significant overlap was found between the SUVmax of benign and malignant lesions making differentiation of lesions difficult.
Many of the studies suffered from having a small cohort and from not providing histological data on all lesions which underwent FDG-PET/CT.
Conclusion.
This systematic review is able to demonstrate that FDG-PET/CT is a useful noninvasive test for discriminating between benign and malignant lesions but has limitations and requires further prospective trials.
American Psychological Association (APA)
Tovmassian, David& Abdul Razak, Muzib& London, Kevin. 2016. The Role of [18F]FDG-PETCT in Predicting Malignant Transformation of Plexiform Neurofibromas in Neurofibromatosis-1. International Journal of Surgical Oncology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107079
Modern Language Association (MLA)
Tovmassian, David…[et al.]. The Role of [18F]FDG-PETCT in Predicting Malignant Transformation of Plexiform Neurofibromas in Neurofibromatosis-1. International Journal of Surgical Oncology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1107079
American Medical Association (AMA)
Tovmassian, David& Abdul Razak, Muzib& London, Kevin. The Role of [18F]FDG-PETCT in Predicting Malignant Transformation of Plexiform Neurofibromas in Neurofibromatosis-1. International Journal of Surgical Oncology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107079