Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients
Joint Authors
Mah, Eunice
Guo, Yi
Bruno, Richard S.
Beam, Jo Ellen
Thompson, Paul D.
Ballard, Kevin D.
Polk, Donna M.
Parker, Beth A.
Source
International Journal of Vascular Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To investigate vascular endothelial function (VEF) responses to a single low-density lipoprotein (LDL) apheresis session in hypercholesterolemic patients undergoing chronic treatment.
Methods.
We measured brachial artery flow-mediated dilation (FMD), plasma lipids, vitamin E (α- and γ-tocopherol), markers of oxidative/nitrative stress (malondialdehyde (MDA) and nitro-γ-tocopherol (NGT)), and regulators of NO metabolism (arginine (ARG) and asymmetric dimethylarginine (ADMA)) prior to (Pre) and immediately following (Post) LDL apheresis and at 1, 3, 7, and 14 d Post in 5 hypercholesterolemic patients ( 52 ± 11 y).
Results.
Relative to Pre, total cholesterol ( 7.8 ± 1.5 mmol/L) and LDL-cholesterol ( 6.2 ± 1.2 mmol/L) were 61% and 70% lower ( P < 0.01 ), respectively, at Post and returned to Pre levels at 14 d.
Brachial FMD responses ( 6.9 ± 3.6 %) and plasma MDA, ARG, and ADMA concentrations were unaffected by LDL apheresis.
Plasma α-tocopherol, γ-tocopherol, and NGT concentrations were 52–69% lower at Post ( P < 0.01 ), and α-tocopherol remained 36% lower at 1 d whereas NGT remained 41% lower at d 3.
Conclusions.
Acute cholesterol reduction by LDL apheresis does not alter VEF, oxidative stress, or NO homeostasis in patients treated chronically for hypercholesterolemia.
American Psychological Association (APA)
Ballard, Kevin D.& Mah, Eunice& Guo, Yi& Bruno, Richard S.& Parker, Beth A.& Beam, Jo Ellen…[et al.]. 2016. Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients. International Journal of Vascular Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107111
Modern Language Association (MLA)
Ballard, Kevin D.…[et al.]. Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients. International Journal of Vascular Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1107111
American Medical Association (AMA)
Ballard, Kevin D.& Mah, Eunice& Guo, Yi& Bruno, Richard S.& Parker, Beth A.& Beam, Jo Ellen…[et al.]. Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients. International Journal of Vascular Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107111