Children and Adolescent Obesity Associates with Pressure-Dependent and Age-Related Increase in Carotid and Femoral Arteries’ Stiffness and Not in Brachial Artery, Indicative of Nonintrinsic Arterial Wall Alteration
Joint Authors
Bia, Daniel
Zócalo, Yanina
Curcio, S.
García-Espinosa, V.
Giachetto, G.
Castro, Juan M.
Arana, Maite
Chiesa, Pedro
Source
International Journal of Vascular Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Aim.
To analyze if childhood obesity associates with changes in elastic, transitional, and/or muscular arteries’ stiffness.
Methods.
221 subjects (4–15 years, 92 females) were assigned to normal weight (NW, n=137) or obesity (OB, n=84) groups, considering their body mass index z-score.
Age groups were defined: 4–8; 8–12; 12–15 years old.
Carotid, femoral, and brachial artery local stiffness was determined through systodiastolic pressure-diameter and stress-strain relationships.
To this end, arterial diameter and peripheral and aortic blood pressure (BP) levels and waveforms were recorded.
Carotid-femoral, femoropedal, and carotid-radial pulse wave velocities were determined to evaluate aortic, lower-limb, and upper-limb regional arterial stiffness, respectively.
Correlation analysis between stiffness parameters and BP was done.
Results.
Compared to NW, OB subjects showed higher peripheral and central BP and carotid and femoral stiffness, reaching statistical significance in subjects aged 12 and older.
Arterial stiffness differences disappeared when levels were normalized for BP.
There were no differences in intrinsic arterial wall stiffness (elastic modulus), BP stiffness relationships, and regional stiffness parameters.
Conclusion.
OB associates with BP-dependent and age-related increase in carotid and femoral (but not brachial) stiffness.
Stiffness changes would not be explained by intrinsic arterial wall alterations but could be associated with the higher BP levels observed in obese children.
American Psychological Association (APA)
García-Espinosa, V.& Curcio, S.& Castro, Juan M.& Arana, Maite& Giachetto, G.& Chiesa, Pedro…[et al.]. 2016. Children and Adolescent Obesity Associates with Pressure-Dependent and Age-Related Increase in Carotid and Femoral Arteries’ Stiffness and Not in Brachial Artery, Indicative of Nonintrinsic Arterial Wall Alteration. International Journal of Vascular Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1107113
Modern Language Association (MLA)
García-Espinosa, V.…[et al.]. Children and Adolescent Obesity Associates with Pressure-Dependent and Age-Related Increase in Carotid and Femoral Arteries’ Stiffness and Not in Brachial Artery, Indicative of Nonintrinsic Arterial Wall Alteration. International Journal of Vascular Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1107113
American Medical Association (AMA)
García-Espinosa, V.& Curcio, S.& Castro, Juan M.& Arana, Maite& Giachetto, G.& Chiesa, Pedro…[et al.]. Children and Adolescent Obesity Associates with Pressure-Dependent and Age-Related Increase in Carotid and Femoral Arteries’ Stiffness and Not in Brachial Artery, Indicative of Nonintrinsic Arterial Wall Alteration. International Journal of Vascular Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1107113
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107113