Renal Blood Flow Response to Angiotensin 1-7 versus Hypertonic Sodium Chloride 7.5% Administration after Acute Hemorrhagic Shock in Rats
Joint Authors
Maleki, Maryam
Nematbakhsh, Mehdi
Source
International Journal of Vascular Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Angiotensin 1-7 (Ang1-7) plays an important role in renal circulation.
Hemorrhagic shock (HS) may cause kidney circulation disturbance, and this study was designed to investigate the renal blood flow (RBF) response to Ang1-7 after HS.
Methods.
27 male Wistar rats were subjected to blood withdrawal to reduce mean arterial pressure (MAP) to 45 mmHg for 45 min.
The animals were treated with saline (group 1), Ang1-7 (300 ng·kg−1 min−1), Ang1-7 in hypertonic sodium chloride 7.5% (group 3), and hypertonic solution alone (group 4).
Results.
MAP was increased in a time-related fashion ( P t i m e < 0.0001 ) in all groups; however, there was a tendency for the increase in MAP in response to hypertonic solution ( P = 0.09 ).
Ang1-7, hypertonic solution, or combination of both increased RBF in groups 2-4, and these were significantly different from saline group ( P = 0.05 ); that is, Ang1-7 leads to a significant increase in RBF to 1.35 ± 0.25 mL/min compared with 0.55 ± 0.12 mL/min in saline group ( P < 0.05 ).
Conclusion.
Although Ang1-7 administration unlike hypertonic solution could not elevate MAP after HS, it potentially could increase RBF similar to hypertonic solution.
This suggested that Ang1-7 recovers RBF after HS when therapeutic opportunities of hypertonic solution are limited.
American Psychological Association (APA)
Maleki, Maryam& Nematbakhsh, Mehdi. 2016. Renal Blood Flow Response to Angiotensin 1-7 versus Hypertonic Sodium Chloride 7.5% Administration after Acute Hemorrhagic Shock in Rats. International Journal of Vascular Medicine،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1107119
Modern Language Association (MLA)
Maleki, Maryam& Nematbakhsh, Mehdi. Renal Blood Flow Response to Angiotensin 1-7 versus Hypertonic Sodium Chloride 7.5% Administration after Acute Hemorrhagic Shock in Rats. International Journal of Vascular Medicine No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1107119
American Medical Association (AMA)
Maleki, Maryam& Nematbakhsh, Mehdi. Renal Blood Flow Response to Angiotensin 1-7 versus Hypertonic Sodium Chloride 7.5% Administration after Acute Hemorrhagic Shock in Rats. International Journal of Vascular Medicine. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1107119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107119