Transition Metal Complexes of Naproxen: Synthesis, Characterization, Forced Degradation Studies, and Analytical Method Verification
Joint Authors
Hasan, Md. Sharif
Abdur Rahman, S. M.
Kayesh, Ruhul
Begum, Farida
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of our current research was to synthesize some transition metal complexes of Naproxen, determine their physical properties, and examine their relative stability under various conditions.
Characterizations of these complexes were done by 1H-NMR, Differential Scanning Calorimetry (DSC), FT-IR, HPLC, and scanning electron microscope (SEM).
Complexes were subjected to acidic, basic, and aqueous hydrolysis as well as oxidation, reduction, and thermal degradation.
Also the reversed phase high-performance liquid chromatography (RP-HPLC) method of Naproxen outlined in USP was verified for the Naproxen-metal complexes, with respect to accuracy, precision, solution stability, robustness, and system suitability.
The melting points of the complexes were higher than that of the parent drug molecule suggesting their thermal stability.
In forced degradation study, complexes were found more stable than the Naproxen itself in all conditions: acidic, basic, oxidation, and reduction media.
All the HPLC verification parameters were found within the acceptable value.
Therefore, it can be concluded from the study that the metal complexes of Naproxen can be more stable drug entity and offer better efficacy and longer shelf life than the parent Naproxen.
American Psychological Association (APA)
Hasan, Md. Sharif& Kayesh, Ruhul& Begum, Farida& Abdur Rahman, S. M.. 2016. Transition Metal Complexes of Naproxen: Synthesis, Characterization, Forced Degradation Studies, and Analytical Method Verification. Journal of Analytical Methods in Chemistry،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1107292
Modern Language Association (MLA)
Hasan, Md. Sharif…[et al.]. Transition Metal Complexes of Naproxen: Synthesis, Characterization, Forced Degradation Studies, and Analytical Method Verification. Journal of Analytical Methods in Chemistry No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1107292
American Medical Association (AMA)
Hasan, Md. Sharif& Kayesh, Ruhul& Begum, Farida& Abdur Rahman, S. M.. Transition Metal Complexes of Naproxen: Synthesis, Characterization, Forced Degradation Studies, and Analytical Method Verification. Journal of Analytical Methods in Chemistry. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1107292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107292