Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS
Joint Authors
Cardoso-Palacios, Carlos
Lanekoff, Ingela
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Counterfeit pharmaceutical drugs imply an increasing threat to the global public health.
It is necessary to have systems to control the products that reach the market and to detect falsified medicines.
In this work, molecules in several pharmaceutical tablets were directly analyzed using nanospray desorption electrospray ionization mass spectrometry (nano-DESI MS).
Nano-DESI is an ambient surface sampling technique which enables sampling of molecules directly from the surface of the tablets without any sample pretreatment.
Both the active pharmaceutical ingredients (APIs) and some excipients were detected in all analyzed tablets.
Principal component analysis was used to analyze mass spectral features from different tablets showing strong clustering between tablets with different APIs.
The obtained results suggest nano-DESI MS as future tool for forensic analysis to discern APIs present in unknown tablet samples.
American Psychological Association (APA)
Cardoso-Palacios, Carlos& Lanekoff, Ingela. 2016. Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS. Journal of Analytical Methods in Chemistry،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1107293
Modern Language Association (MLA)
Cardoso-Palacios, Carlos& Lanekoff, Ingela. Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS. Journal of Analytical Methods in Chemistry No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1107293
American Medical Association (AMA)
Cardoso-Palacios, Carlos& Lanekoff, Ingela. Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS. Journal of Analytical Methods in Chemistry. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1107293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107293