Understanding Muscle Dysfunction in Chronic Fatigue Syndrome
Joint Authors
Rutherford, Gina
Manning, Philip
Newton, Julia L.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-22
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Introduction.
Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a debilitating disorder of unknown aetiology, characterised by severe disabling fatigue in the absence of alternative diagnosis.
Historically, there has been a tendency to draw psychological explanations for the origin of fatigue; however, this model is at odds with findings that fatigue and accompanying symptoms may be explained by central and peripheral pathophysiological mechanisms, including effects of the immune, oxidative, mitochondrial, and neuronal pathways.
For example, patient descriptions of their fatigue regularly cite difficulty in maintaining muscle activity due to perceived lack of energy.
This narrative review examined the literature for evidence of biochemical dysfunction in CFS/ME at the skeletal muscle level.
Methods.
Literature was examined following searches of PUB MED, MEDLINE, and Google Scholar, using key words such as CFS/ME, immune, autoimmune, mitochondria, muscle, and acidosis.
Results.
Studies show evidence for skeletal muscle biochemical abnormality in CFS/ME patients, particularly in relation to bioenergetic dysfunction.
Discussion.
Bioenergetic muscle dysfunction is evident in CFS/ME, with a tendency towards an overutilisation of the lactate dehydrogenase pathway following low-level exercise, in addition to slowed acid clearance after exercise.
Potentially, these abnormalities may lead to the perception of severe fatigue in CFS/ME.
American Psychological Association (APA)
Rutherford, Gina& Manning, Philip& Newton, Julia L.. 2016. Understanding Muscle Dysfunction in Chronic Fatigue Syndrome. Journal of Aging Research،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1107417
Modern Language Association (MLA)
Rutherford, Gina…[et al.]. Understanding Muscle Dysfunction in Chronic Fatigue Syndrome. Journal of Aging Research No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1107417
American Medical Association (AMA)
Rutherford, Gina& Manning, Philip& Newton, Julia L.. Understanding Muscle Dysfunction in Chronic Fatigue Syndrome. Journal of Aging Research. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1107417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107417