Baicalin and Baicalein Inhibit Src Tyrosine Kinase and Production of IL-6
Joint Authors
Blažeković, Biljana
Vladimir-Knežević, Sanda
Jelić, Dubravko
Lower-Nedza, Agnieszka D.
Brantner, Adelheid H.
Bian, Baolin
Yang, Jian
Brajša, Karmen
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Flavonoids play an important role in the treatment of various diseases, as they are able to inhibit reactive oxygen species, which cause damage to cells and tissues which may lead to increased risk of inflammatory diseases.
Baicalin and baicalein, two flavonoids found in the roots of Scutellaria baicalensis, in the leaves of Thymus vulgaris and Oroxylum indicum, were tested for their anti-inflammatory activity as well as for their cytotoxicity.
Thereby the two compounds were investigated on Src tyrosine kinase inhibition and inhibition of production of interleukin (IL-6) in lipopolysaccharide- (LPS-) stimulated THP-1 cells.
Additionally, the THP-1 cell line was used for the determination of the cytotoxicity.
Both baicalin and baicalein showed some anti-inflammatory properties, while baicalein turned out to be the more active compound with higher inhibitory activities on both Src tyrosine kinase and production of cytokine IL-6.
Baicalin and baicalein showed no signs of cytotoxicity in the MTS cytotoxicity assay in THP-1 cells.
American Psychological Association (APA)
Jelić, Dubravko& Blažeković, Biljana& Bian, Baolin& Yang, Jian& Brajša, Karmen& Vladimir-Knežević, Sanda…[et al.]. 2016. Baicalin and Baicalein Inhibit Src Tyrosine Kinase and Production of IL-6. Journal of Chemistry،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1107593
Modern Language Association (MLA)
Blažeković, Biljana…[et al.]. Baicalin and Baicalein Inhibit Src Tyrosine Kinase and Production of IL-6. Journal of Chemistry No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1107593
American Medical Association (AMA)
Jelić, Dubravko& Blažeković, Biljana& Bian, Baolin& Yang, Jian& Brajša, Karmen& Vladimir-Knežević, Sanda…[et al.]. Baicalin and Baicalein Inhibit Src Tyrosine Kinase and Production of IL-6. Journal of Chemistry. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1107593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107593