Synthesis and Bacteriostatic Activities of Bis(thiourea) Derivatives with Variable Chain Length
Joint Authors
Abd Halim, Ainaa Nadiah
Ngaini, Zainab
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A series of 1,4-bis(decoxyphenyl)carbamothioyl-terephthalamide derivatives was successfully synthesised by reaction of benzene-1,4-dicarbonyl isothiocyanate intermediates with long alkyl chain.
The alkylation was performed via Williamson etherification of 4-acetamidophenol with bromoalkanes.
The synthesised bis(thiourea) derivatives differed in the chain length, C nH2n+1, where n = 10 , 12, and 14.
The structures of all compounds were characterised by elemental CHN analysis, IR, 1H, and 13C NMR spectroscopies.
Bacteriostatic activities of bis(thiourea derivatives which consisted of two folds of N-H, C=O, and C=S and long alkyl chain substituents were carried out against Gram-negative bacteria (Escherichia coli, ATCC 25922) via turbidimetric kinetic method.
Bis(thiourea) derivatives with n = 10 and n = 12 displayed excellent activity against E.
coli with MIC of 135 µg/mL and 145 µg/mL, respectively, while bis(thiourea) derivatives with n = 14 acted as cutoff point with no antibacterial properties.
Similar trend was observed in binding affinity to the active site of enoyl ACP reductase (FabI), which demonstrated binding free energy of - 5.3 Kcal/mol and - 4.9 and - 4.8 Kcal/mol, respectively.
American Psychological Association (APA)
Abd Halim, Ainaa Nadiah& Ngaini, Zainab. 2016. Synthesis and Bacteriostatic Activities of Bis(thiourea) Derivatives with Variable Chain Length. Journal of Chemistry،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107599
Modern Language Association (MLA)
Abd Halim, Ainaa Nadiah& Ngaini, Zainab. Synthesis and Bacteriostatic Activities of Bis(thiourea) Derivatives with Variable Chain Length. Journal of Chemistry No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1107599
American Medical Association (AMA)
Abd Halim, Ainaa Nadiah& Ngaini, Zainab. Synthesis and Bacteriostatic Activities of Bis(thiourea) Derivatives with Variable Chain Length. Journal of Chemistry. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107599
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107599