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Green Production of Indolylquinones, Derivatives of Perezone, and Related Molecules, Promising Antineoplastic Compounds
Joint Authors
Escobedo-González, René Gerardo
Pérez Martínez, Héctor
Gómez, Gabriela
Serrano, Juan Nava
Carranza Téllez, Vladimir
Vargas-Requena, C. L.
Miranda Ruvalcaba, René
Martínez, Joel Omar
Nicolás Vazquez, María Inés
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A green approach to produce the indolyl derivatives from four natural quinones (perezone, isoperezone, menadione, and plumbagin) was performed; in this regard, a comparative study was accomplished among the typical mantle heating and three nonconventional activating modes of reaction (microwave, near-infrared, and high speed ball milling or tribochemical), under solventless conditions and using bentonitic clay as a catalyst.
In addition, the tribochemical production of isoperezone from perezone is also commented on.
It is also worth noting that the cytotoxicity of the synthesized indolylquinones in human breast cancer cell was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, with the 3-indolylisoperezone being the most active.
The structural attribution of the target molecules was performed by typical spectroscopic procedures; moreover, the experimental and computed 1H and 13C NMR chemical shifts data, with previous acquisition of the corresponding minimum energetic structures, were in good agreement.
American Psychological Association (APA)
Escobedo-González, René Gerardo& Pérez Martínez, Héctor& Nicolás Vazquez, María Inés& Martínez, Joel Omar& Gómez, Gabriela& Serrano, Juan Nava…[et al.]. 2016. Green Production of Indolylquinones, Derivatives of Perezone, and Related Molecules, Promising Antineoplastic Compounds. Journal of Chemistry،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1107646
Modern Language Association (MLA)
Escobedo-González, René Gerardo…[et al.]. Green Production of Indolylquinones, Derivatives of Perezone, and Related Molecules, Promising Antineoplastic Compounds. Journal of Chemistry No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1107646
American Medical Association (AMA)
Escobedo-González, René Gerardo& Pérez Martínez, Héctor& Nicolás Vazquez, María Inés& Martínez, Joel Omar& Gómez, Gabriela& Serrano, Juan Nava…[et al.]. Green Production of Indolylquinones, Derivatives of Perezone, and Related Molecules, Promising Antineoplastic Compounds. Journal of Chemistry. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1107646
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107646