A Synthetic Approach to Pyrazolopyranopyrimidinones and Pyrazolopyranooxazinones as Antimicrobial Agents
Joint Authors
Elziaty, A. K.
Bassioni, G.
Hassan, A. M. A.
Derbala, H. A.
Abdel-Aziz, M. S.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The hitherto unknown 6-amino-4-(2-chloro-5-nitrophenyl)-3-methyl-1,4-dihydropyrano[2,3-c] pyrazole-5-carbonitrile 1a was synthesized.
Both 1a and its 2,4 dichlorophenyl derivative 1b were utilized as building blocks for the preparation of novel class of pyrazolopyrano-[oxazines 2a–d and pyrimidinones 3a–d].
Synthesis of these compounds was achieved by two alternative acylation steps followed by ammonolysis.
The structures of the synthesized compounds were elucidated by spectral data and elemental analysis.
Screening and evaluation of these products as antimicrobial agents showed that the derivatives 1b, 2s, 3b, and 3d possess a potent activity.
American Psychological Association (APA)
Elziaty, A. K.& Bassioni, G.& Hassan, A. M. A.& Derbala, H. A.& Abdel-Aziz, M. S.. 2016. A Synthetic Approach to Pyrazolopyranopyrimidinones and Pyrazolopyranooxazinones as Antimicrobial Agents. Journal of Chemistry،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107695
Modern Language Association (MLA)
Elziaty, A. K.…[et al.]. A Synthetic Approach to Pyrazolopyranopyrimidinones and Pyrazolopyranooxazinones as Antimicrobial Agents. Journal of Chemistry No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1107695
American Medical Association (AMA)
Elziaty, A. K.& Bassioni, G.& Hassan, A. M. A.& Derbala, H. A.& Abdel-Aziz, M. S.. A Synthetic Approach to Pyrazolopyranopyrimidinones and Pyrazolopyranooxazinones as Antimicrobial Agents. Journal of Chemistry. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107695