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Novel Palladium(II) and Platinum(II) Complexes with a Fluoropiperazinyl Based Ligand Exhibiting High Cytotoxicity and Anticancer Activity In Vitro
Joint Authors
Abu-Safieh, Kayed A.
Abu-Surrah, Adnan S.
Tabba, Hani D.
AlMasri, Huda A.
Bawadi, Randa M.
Boudjelal, Fadila M.
Tahtamouni, Lubna H.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
cis-Dichloro-palladium(II) and cis-dichloro-platinum(II) complexes (2, 4) of the general formula [M(N-N)Cl2] (M=Pd(II) and Pt(II), N-N= 1,2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl) benzene, (DFMPB)) and the dicationic palladium(II) complex [Pd(N-N)(CH3CN)2](BF4)2 (3) have been prepared and characterized by elemental analysis, 1H-NMR-, mass spectroscopy, and IR spectroscopy.
The cytotoxic effect of these complexes against MDA-231 and MCF-7 human breast cancer cell lines and K562 human leukemia cell line has been studied.
The influence was dose dependent and varies with cell type.
The palladium(II) complex (2) showed superior cytotoxic effect compared with the corresponding platinum(II) complex and the standard, cisplatin, when tested against all the above cell lines.
American Psychological Association (APA)
Abu-Safieh, Kayed A.& Abu-Surrah, Adnan S.& Tabba, Hani D.& AlMasri, Huda A.& Bawadi, Randa M.& Boudjelal, Fadila M.…[et al.]. 2016. Novel Palladium(II) and Platinum(II) Complexes with a Fluoropiperazinyl Based Ligand Exhibiting High Cytotoxicity and Anticancer Activity In Vitro. Journal of Chemistry،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107751
Modern Language Association (MLA)
Abu-Safieh, Kayed A.…[et al.]. Novel Palladium(II) and Platinum(II) Complexes with a Fluoropiperazinyl Based Ligand Exhibiting High Cytotoxicity and Anticancer Activity In Vitro. Journal of Chemistry No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1107751
American Medical Association (AMA)
Abu-Safieh, Kayed A.& Abu-Surrah, Adnan S.& Tabba, Hani D.& AlMasri, Huda A.& Bawadi, Randa M.& Boudjelal, Fadila M.…[et al.]. Novel Palladium(II) and Platinum(II) Complexes with a Fluoropiperazinyl Based Ligand Exhibiting High Cytotoxicity and Anticancer Activity In Vitro. Journal of Chemistry. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107751
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107751