![](/images/graphics-bg.png)
Nonlinear and Robust Control Strategy Based on Chemotherapy to Minimize the HIV Concentration in Blood Plasma
Joint Authors
Aguilar-López, R.
Gómez-Acata, Rigel Valentín
Lara-Cisneros, Gerardo
Femat, Ricardo
Source
Journal of Control Science and Engineering
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Electronic engineering
Information Technology and Computer Science
Abstract EN
A nonlinear PI-type control strategy is designed in order to minimize the HIV concentration in blood plasma, via medical drug injection, under the framework of bounded uncertain input disturbances.
For control design it is considered a simplified mathematical model of the virus infection as a benchmark.
The model is based on mass balances of healthy cells, infected cells, and the virus concentrations.
The proposed controller contains a nonlinear feedback PI structure of bounded functions of the regulation error.
The closed-loop stability of the system is analyzed via Lyapunov technique, in which robustness against system disturbances is demonstrated.
Numerical experiments show a satisfactory performance of the proposed methodology as a HIV therapy, in which the virion particles and the infected CD4+T cells are minimized and, as an interesting result, the drug dosage can be suspended, thus avoiding drug resistance from the virus.
Finally, the proposed controller is compared to a standard sliding-mode and hyperbolic tangent controllers showing better performance.
American Psychological Association (APA)
Aguilar-López, R.& Gómez-Acata, Rigel Valentín& Lara-Cisneros, Gerardo& Femat, Ricardo. 2016. Nonlinear and Robust Control Strategy Based on Chemotherapy to Minimize the HIV Concentration in Blood Plasma. Journal of Control Science and Engineering،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1107907
Modern Language Association (MLA)
Aguilar-López, R.…[et al.]. Nonlinear and Robust Control Strategy Based on Chemotherapy to Minimize the HIV Concentration in Blood Plasma. Journal of Control Science and Engineering No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1107907
American Medical Association (AMA)
Aguilar-López, R.& Gómez-Acata, Rigel Valentín& Lara-Cisneros, Gerardo& Femat, Ricardo. Nonlinear and Robust Control Strategy Based on Chemotherapy to Minimize the HIV Concentration in Blood Plasma. Journal of Control Science and Engineering. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1107907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107907