Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in IschemiaReperfusion Injury and Cardiac Hypertrophy
Joint Authors
Irwin, Michael G.
Pang, Lei
Cai, Yin
Tang, Eva Hoi Ching
Ma, Haichun
Xia, Zhengyuan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Prostaglandin E2 (PGE2) is an endogenous lipid mediator, produced from the metabolism of arachidonic acids, upon the sequential actions of phospholipase A2, cyclooxygenases, and prostaglandin E synthases.
The various biological functions governed by PGE2 are mediated through its four distinct prostaglandin E receptors (EPs), designated as EP1, EP2, EP3, and EP4, among which the EP4 receptor is the one most widely distributed in the heart.
The availability of global or cardiac-specific EP4 knockout mice and the development of selective EP4 agonists/antagonists have provided substantial evidence to support the role of EP4 receptor in the heart.
However, like any good drama, activation of PGE2-EP4 signaling exerts both protective and detrimental effects in the ischemic heart disease.
Thus, the primary object of this review is to provide a comprehensive overview of the current progress of the PGE2-EP4 signaling in ischemic heart diseases, including cardiac hypertrophy and myocardial ischemia/reperfusion injury.
A better understanding of PGE2-EP4 signaling should promote the development of more effective therapeutic approaches to treat the ischemic heart diseases without triggering unwanted side effects.
American Psychological Association (APA)
Pang, Lei& Cai, Yin& Tang, Eva Hoi Ching& Irwin, Michael G.& Ma, Haichun& Xia, Zhengyuan. 2016. Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in IschemiaReperfusion Injury and Cardiac Hypertrophy. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1107956
Modern Language Association (MLA)
Pang, Lei…[et al.]. Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in IschemiaReperfusion Injury and Cardiac Hypertrophy. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1107956
American Medical Association (AMA)
Pang, Lei& Cai, Yin& Tang, Eva Hoi Ching& Irwin, Michael G.& Ma, Haichun& Xia, Zhengyuan. Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in IschemiaReperfusion Injury and Cardiac Hypertrophy. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1107956
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107956