Glucose >200 mgdL during Continuous Glucose Monitoring Identifies Adult Patients at Risk for Development of Cystic Fibrosis Related Diabetes
Joint Authors
Accurso, Frank J.
Sontag, Marci K.
Taylor-Cousar, J. L.
Janssen, J. S.
Wilson, A.
Clair, C. G. St.
Pickard, K. M.
Jones, M. C.
Brayshaw, S. J.
Chacon, C. S.
Barboa, C. M.
Nichols, D. P.
Saavedra, M. T.
Nick, J. A.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Rationale.
Cystic fibrosis related diabetes (CFRD) is the most common comorbidity in patients with CF.
In spite of increased screening, diagnosis, and treatment of CFRD, the mortality rate in patients with CFRD still far exceeds the mortality rate in those without CFRD.
Guidelines suggest that screening for CFRD be performed annually using the 2-hour 75-gram oral glucose tolerance test (OGTT).
Adherence to recommended screening has been poor, with only approximately one-quarter of adults with CF undergoing OGTT in 2014.
Use of continuous glucose monitoring (CGM) for diagnosis may become an alternative.
Objectives.
Our objective was to determine whether abnormal CGM predicts subsequent development of CFRD, lung function, and body mass index (BMI) decline and increased rate of CF pulmonary exacerbations in adults with CF.
Methods.
In a prospective single center pilot trial from September 2009 to September 2010, 21 adult patients due for routine OGTT were recruited to complete simultaneous 3-day CGM and 2-hour 75 gram OGTT.
Subsequently, clinical information was reviewed from 2008 to 2015.
Conclusions.
There was a moderate correlation between interpreted results of 2-hour OGTT and CGM (p=0.03); CGM indicated a greater level of glucose impairment than OGTT.
Glucose >200 mg/dL by CGM predicted development of CFRD (p=0.0002).
American Psychological Association (APA)
Taylor-Cousar, J. L.& Janssen, J. S.& Wilson, A.& Clair, C. G. St.& Pickard, K. M.& Jones, M. C.…[et al.]. 2016. Glucose >200 mgdL during Continuous Glucose Monitoring Identifies Adult Patients at Risk for Development of Cystic Fibrosis Related Diabetes. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1107965
Modern Language Association (MLA)
Taylor-Cousar, J. L.…[et al.]. Glucose >200 mgdL during Continuous Glucose Monitoring Identifies Adult Patients at Risk for Development of Cystic Fibrosis Related Diabetes. Journal of Diabetes Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1107965
American Medical Association (AMA)
Taylor-Cousar, J. L.& Janssen, J. S.& Wilson, A.& Clair, C. G. St.& Pickard, K. M.& Jones, M. C.…[et al.]. Glucose >200 mgdL during Continuous Glucose Monitoring Identifies Adult Patients at Risk for Development of Cystic Fibrosis Related Diabetes. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1107965
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107965