Swimming Exercise Alleviated Insulin Resistance by Regulating Tripartite Motif Family Protein 72 Expression and AKT Signal Pathway in Sprague-Dawley Rats Fed with High-Fat Diet
Joint Authors
Qi, Jie
Yang, Bo
Ren, Cailing
Fu, Jian
Zhang, Jun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We aimed to investigate whether swimming exercise could improve insulin resistance (IR) by regulating tripartite motif family protein 72 (TRIM72) expression and AKT signal pathway in rats fed with high-fat diet.
Five-week-old rats were classified into 3 groups: standard diet as control (CON), high-fat diet (HFD), and HFD plus swimming exercise (Ex-HFD).
After 8 weeks, glucose infusion rate (GIR), markers of oxidative stress, mRNA and protein expression of TRIM72, protein of IRS, p-AKTSer473, and AKT were determined in quadriceps muscles.
Compared with HFD, the GIR, muscle SOD, and GSH-Px were significantly increased (p<0.05, resp.), whereas muscle MDA and 8-OHdG levels were significantly decreased (p<0.05 and p<0.01) in Ex-HFD.
Expression levels of TRIM72 mRNA and protein in muscles were significantly reduced (p<0.05 and p<0.01), whereas protein expression levels of IRS-1, p-AKTSer473, and AKT were significantly increased in Ex-HFD compared with HFD (p<0.01, p<0.01, and p<0.05).
These results suggest that an 8-week swimming exercise improves HFD-induced insulin resistance maybe through a reduction of TRIM72 in skeletal muscle and enhancement of AKT signal transduction.
American Psychological Association (APA)
Qi, Jie& Yang, Bo& Ren, Cailing& Fu, Jian& Zhang, Jun. 2016. Swimming Exercise Alleviated Insulin Resistance by Regulating Tripartite Motif Family Protein 72 Expression and AKT Signal Pathway in Sprague-Dawley Rats Fed with High-Fat Diet. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1107968
Modern Language Association (MLA)
Qi, Jie…[et al.]. Swimming Exercise Alleviated Insulin Resistance by Regulating Tripartite Motif Family Protein 72 Expression and AKT Signal Pathway in Sprague-Dawley Rats Fed with High-Fat Diet. Journal of Diabetes Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1107968
American Medical Association (AMA)
Qi, Jie& Yang, Bo& Ren, Cailing& Fu, Jian& Zhang, Jun. Swimming Exercise Alleviated Insulin Resistance by Regulating Tripartite Motif Family Protein 72 Expression and AKT Signal Pathway in Sprague-Dawley Rats Fed with High-Fat Diet. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1107968
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107968