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Atypical Diabetic Foot Ulcer Keratinocyte Protein Signaling Correlates with Impaired Wound Healing
Joint Authors
Hoke, Glenn D.
Ramos, Corrine
Hoke, Nicholas N.
Crossland, Mary C.
Shawler, Lisa G.
Boykin, Joseph V.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetes mellitus is associated with chronic diabetic foot ulcers (DFUs) and wound infections often resulting in lower extremity amputations.
The protein signaling architecture of the mechanisms responsible for impaired DFU healing has not been characterized.
In this preliminary clinical study, the intracellular levels of proteins involved in signal transduction networks relevant to wound healing were non-biasedly measured using reverse-phase protein arrays (RPPA) in keratinocytes isolated from DFU wound biopsies.
RPPA allows for the simultaneous documentation and assessment of the signaling pathways active in each DFU.
Thus, RPPA provides for the accurate mapping of wound healing pathways associated with apoptosis, proliferation, senescence, survival, and angiogenesis.
From the study data, we have identified potential diagnostic, or predictive, biomarkers for DFU wound healing derived from the ratios of quantified signaling protein expressions within interconnected pathways.
These biomarkers may allow physicians to personalize therapeutic strategies for DFU management on an individual basis based upon the signaling architecture present in each wound.
Additionally, we have identified altered, interconnected signaling pathways within DFU keratinocytes that may help guide the development of therapeutics to modulate these dysregulated pathways, many of which parallel the therapeutic targets which are the hallmarks of molecular therapies for treating cancer.
American Psychological Association (APA)
Hoke, Glenn D.& Ramos, Corrine& Hoke, Nicholas N.& Crossland, Mary C.& Shawler, Lisa G.& Boykin, Joseph V.. 2016. Atypical Diabetic Foot Ulcer Keratinocyte Protein Signaling Correlates with Impaired Wound Healing. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1107970
Modern Language Association (MLA)
Hoke, Glenn D.…[et al.]. Atypical Diabetic Foot Ulcer Keratinocyte Protein Signaling Correlates with Impaired Wound Healing. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1107970
American Medical Association (AMA)
Hoke, Glenn D.& Ramos, Corrine& Hoke, Nicholas N.& Crossland, Mary C.& Shawler, Lisa G.& Boykin, Joseph V.. Atypical Diabetic Foot Ulcer Keratinocyte Protein Signaling Correlates with Impaired Wound Healing. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1107970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107970