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Free Fatty Acids Activate Renin-Angiotensin System in 3T3-L1 Adipocytes through Nuclear Factor-kappa B Pathway
Joint Authors
Zhang, Hua
Chen, Hong
Sun, Jia
Luo, Jinhua
Ruan, Yuting
Xiu, Liangchang
Fang, Bimei
Wang, Ming
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The activity of a local renin-angiotensin system (RAS) in the adipose tissue is closely associated with obesity-related diseases.
However, the mechanism of RAS activation in adipose tissue is still unknown.
In the current study, we found that palmitic acid (PA), one kind of free fatty acid, induced the activity of RAS in 3T3-L1 adipocytes.
In the presence of fetuin A (Fet A), PA upregulated the expression of angiotensinogen (AGT) and angiotensin type 1 receptor (AT1R) and stimulated the secretion of angiotensin II (ANG II) in 3T3-L1 adipocytes.
Moreover, the activation of RAS in 3T3-L1 adipocytes was blocked when we blocked Toll-like receptor 4 (TLR4) signaling pathway using TAK242 or NF-κB signaling pathway using BAY117082.
Together, our results have identified critical molecular mechanisms linking PA/TLR4/NF-κB signaling pathway to the activity of the local renin-angiotensin system in adipose tissue.
American Psychological Association (APA)
Sun, Jia& Luo, Jinhua& Ruan, Yuting& Xiu, Liangchang& Fang, Bimei& Zhang, Hua…[et al.]. 2015. Free Fatty Acids Activate Renin-Angiotensin System in 3T3-L1 Adipocytes through Nuclear Factor-kappa B Pathway. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107971
Modern Language Association (MLA)
Sun, Jia…[et al.]. Free Fatty Acids Activate Renin-Angiotensin System in 3T3-L1 Adipocytes through Nuclear Factor-kappa B Pathway. Journal of Diabetes Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1107971
American Medical Association (AMA)
Sun, Jia& Luo, Jinhua& Ruan, Yuting& Xiu, Liangchang& Fang, Bimei& Zhang, Hua…[et al.]. Free Fatty Acids Activate Renin-Angiotensin System in 3T3-L1 Adipocytes through Nuclear Factor-kappa B Pathway. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107971
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107971