Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe−− Mice Fed with High-Fat Diet
Joint Authors
Wang, Shuang-Xi
Liu, Zhan
Li, Peng
Zhao, Zhi-Hong
Zhang, Yu
Ma, Zhi-Min
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Backgrounds.
VitB6 deficiency has been associated with a number of adverse health effects.
However, the effects of VitB6 in metabolic syndrome are poorly understood.
Methods.
VitB6 (50 mg/kg/day) was given to Apoe-/- mice with hkdigh-fat diet (HFD) for 8 weeks.
Endothelial dysfunction, insulin resistance, and hepatic lipid contents were determined.
Results.
VitB6 administration remarkably increased acetylcholine-induced endothelium-dependent relaxation and decreased random blood glucose level in Apoe-/- mice fed with HFD.
In addition, VitB6 improved the tolerance of glucose and insulin, normalized the histopathology of liver, and reduced hepatic lipid accumulation but did not affect the liver functions.
Clinical and biochemical analysis indicated that the levels of VitB6 were decreased in patients with fatty liver.
Conclusions.
Vitamin B6 prevents endothelial dysfunction, insulin resistance, and hepatic lipid accumulation in Apoe-/- mice fed with HFD.
Supplementation of VitB6 should be considered to prevent metabolic syndrome.
American Psychological Association (APA)
Liu, Zhan& Li, Peng& Zhao, Zhi-Hong& Zhang, Yu& Ma, Zhi-Min& Wang, Shuang-Xi. 2015. Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe−− Mice Fed with High-Fat Diet. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1107980
Modern Language Association (MLA)
Liu, Zhan…[et al.]. Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe−− Mice Fed with High-Fat Diet. Journal of Diabetes Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1107980
American Medical Association (AMA)
Liu, Zhan& Li, Peng& Zhao, Zhi-Hong& Zhang, Yu& Ma, Zhi-Min& Wang, Shuang-Xi. Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe−− Mice Fed with High-Fat Diet. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1107980
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107980