Inhibition of NA+H+ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats
Joint Authors
Wang, Shuang-Xi
Li, Peng
Chen, Geng-Rong
Wang, Fu
Xu, Ping
Liu, Li-Ying
Yin, Ya-Ling
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
It has been recognized that sodium hydrogen exchanger 1 (NHE1) is involved in the development of diabetic nephropathy.
The role of NHE1 in kidney dysfunction induced by advanced glycation end products (AGEs) remains unknown.
Renal damage was induced by AGEs via tail vein injections in rats.
Function and morphology of kidney were determined.
Compared to vehicle- or BSA-treated rats, AGEs caused abnormalities of kidney structures and functions in rats, accompanied with higher MDA level and lower GSH content.
Gene expressions of NHE1 gene and TGF-β1 in the renal cortex and urine were also increased in AGEs-injected rats.
Importantly, all these detrimental effects induced by AGEs were reversed by inhibition of NHE1 or suppression of oxidative stress.
These pieces of data demonstrated that AGEs may activate NHE1 to induce renal damage, which is related to TGF-β1.
American Psychological Association (APA)
Li, Peng& Chen, Geng-Rong& Wang, Fu& Xu, Ping& Liu, Li-Ying& Yin, Ya-Ling…[et al.]. 2015. Inhibition of NA+H+ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1107984
Modern Language Association (MLA)
Li, Peng…[et al.]. Inhibition of NA+H+ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1107984
American Medical Association (AMA)
Li, Peng& Chen, Geng-Rong& Wang, Fu& Xu, Ping& Liu, Li-Ying& Yin, Ya-Ling…[et al.]. Inhibition of NA+H+ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1107984
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107984