Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives
Joint Authors
Pithadia, Amit
Brender, Jeffrey R.
Fierke, Carol A.
Ramamoorthy, Ayyalusamy
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Fibrillar aggregates of human islet amyloid polypeptide, hIAPP, a pathological feature seen in some diabetes patients, are a likely causative agent for pancreatic beta-cell toxicity, leading to a transition from a state of insulin resistance to type II diabetes through the loss of insulin producing beta-cells by hIAPP induced toxicity.
Because of the probable link between hIAPP and the development of type II diabetes, there has been strong interest in developing reagents to study the aggregation of hIAPP and possible therapeutics to block its toxic effects.
Natural products are a class of compounds with interesting pharmacological properties against amyloids which have made them interesting targets to study hIAPP.
Specifically, the ability of polyphenolic natural products, EGCG, curcumin, and resveratrol, to modulate the aggregation of hIAPP is discussed.
Furthermore, we have outlined possible mechanistic discoveries of the interaction of these small molecules with the peptide and how they may mitigate toxicity associated with peptide aggregation.
These abundantly found agents have been long used to combat diseases for many years and may serve as useful templates toward developing therapeutics against hIAPP aggregation and toxicity.
American Psychological Association (APA)
Pithadia, Amit& Brender, Jeffrey R.& Fierke, Carol A.& Ramamoorthy, Ayyalusamy. 2015. Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1107998
Modern Language Association (MLA)
Pithadia, Amit…[et al.]. Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives. Journal of Diabetes Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1107998
American Medical Association (AMA)
Pithadia, Amit& Brender, Jeffrey R.& Fierke, Carol A.& Ramamoorthy, Ayyalusamy. Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1107998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107998