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Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory
Joint Authors
López-Gálvez, María Isabel
Romero-Aroca, Pedro
Baget-Bernaldiz, Marc
Pareja-Rios, Alicia
Navarro-Gil, Raul
Verges, Raquel
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-28
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Diabetic macular edema (DME) can cause blindness in diabetic patients suffering from diabetic retinopathy (DR).
DM parameters controls (glycemia, arterial tension, and lipids) are the gold standard for preventing DR and DME.
Although the vascular endothelial growth factor (VEGF) is known to play a role in the development of DME, the pathological processes leading to the onset of this disease are highly complex and the exact sequence in which they occur is still not completely understood.
Angiogenesis and inflammation have been shown to be involved in the pathogenesis of this disease.
However, it still remains to be clarified whether angiogenesis following VEGF overexpression is a cause or a consequence of inflammation.
This paper provides a review of the data currently available, focusing on VEGF, angiogenesis, and inflammation.
Our analysis suggests that angiogenesis and inflammation act interdependently during the development of DME.
Knowledge of DME etiology seems to be important in treatments with anti-VEGF or anti-inflammatory drugs.
Current diagnostic techniques do not permit us to differentiate between both etiologies.
In the future, diagnosing the physiopathology of each patient with DME will help us to select the most effective drug.
American Psychological Association (APA)
Romero-Aroca, Pedro& Baget-Bernaldiz, Marc& Pareja-Rios, Alicia& López-Gálvez, María Isabel& Navarro-Gil, Raul& Verges, Raquel. 2016. Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1108003
Modern Language Association (MLA)
Romero-Aroca, Pedro…[et al.]. Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory. Journal of Diabetes Research No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1108003
American Medical Association (AMA)
Romero-Aroca, Pedro& Baget-Bernaldiz, Marc& Pareja-Rios, Alicia& López-Gálvez, María Isabel& Navarro-Gil, Raul& Verges, Raquel. Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1108003
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108003