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Renin-Angiotensin System Gene Variants and Type 2 Diabetes Mellitus: Influence of Angiotensinogen
Joint Authors
Sattar, Munavvar A.
Abdullah, Nor Azizan
Joyce-Tan, Siew Mei
Zain, Shamsul Mohd
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Genome-wide association studies (GWAS) have been successfully used to call for variants associated with diseases including type 2 diabetes mellitus (T2DM).
However, some variants are not included in the GWAS to avoid penalty in multiple hypothetic testing.
Thus, candidate gene approach is still useful even at GWAS era.
This study attempted to assess whether genetic variations in the renin-angiotensin system (RAS) and their gene interactions are associated with T2DM risk.
We genotyped 290 T2DM patients and 267 controls using three genes of the RAS, namely, angiotensin converting enzyme (ACE), angiotensinogen (AGT), and angiotensin II type 1 receptor (AGTR1).
There were significant differences in allele frequencies between cases and controls for AGT variants ( P = 0.05 ) but not for ACE and AGTR1.
Haplotype TCG of the AGT was associated with increased risk of T2DM (OR 1.92, 95% CI 1.15–3.20, permuted P = 0.012 ); however, no evidence of significant gene-gene interactions was seen.
Nonetheless, our analysis revealed that the associations of the AGT variants with T2DM were independently associated.
Thus, this study suggests that genetic variants of the RAS can modestly influence the T2DM risk.
American Psychological Association (APA)
Joyce-Tan, Siew Mei& Zain, Shamsul Mohd& Sattar, Munavvar A.& Abdullah, Nor Azizan. 2015. Renin-Angiotensin System Gene Variants and Type 2 Diabetes Mellitus: Influence of Angiotensinogen. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108005
Modern Language Association (MLA)
Joyce-Tan, Siew Mei…[et al.]. Renin-Angiotensin System Gene Variants and Type 2 Diabetes Mellitus: Influence of Angiotensinogen. Journal of Diabetes Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108005
American Medical Association (AMA)
Joyce-Tan, Siew Mei& Zain, Shamsul Mohd& Sattar, Munavvar A.& Abdullah, Nor Azizan. Renin-Angiotensin System Gene Variants and Type 2 Diabetes Mellitus: Influence of Angiotensinogen. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108005