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The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes
Joint Authors
Zhong, Jixin
Wang, Yanan
Zhang, Xiangzhi
Liu, Ziwei
Yang, Yuan
Gong, Quan
Ren, Boxu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Significance.
With an alarming increase in recent years, diabetes mellitus has become a global challenge.
Despite advances in treatment of diabetes mellitus, currently, medications available are unable to control the progression of diabetes and its complications.
Growing evidence suggests that inflammation is an important pathogenic mediator in the development of diabetes mellitus.
The perspectives including suggestions for new therapies involving the shift from metabolic stress to inflammation should be taken into account.
Critical Issues.
High-mobility group box 1 (HMGB1), a nonhistone nuclear protein regulating gene expression, was rediscovered as an endogenous danger signal molecule to trigger inflammatory responses when released into extracellular milieu in the late 1990s.
Given the similarities of inflammatory response in the development of T2D, we will discuss the potential implication of HMGB1 in the pathogenesis of T2D.
Importantly, we will summarize and renovate the role of HMGB1 and HMGB1-mediated inflammatory pathways in adipose tissue inflammation, insulin resistance, and islet dysfunction.
Future Directions.
HMGB1 and its downstream receptors RAGE and TLRs may serve as potential antidiabetic targets.
Current and forthcoming projects in this territory will pave the way for prospective approaches targeting the center of HMGB1-mediated inflammation to improve T2D and its complications.
American Psychological Association (APA)
Wang, Yanan& Zhong, Jixin& Zhang, Xiangzhi& Liu, Ziwei& Yang, Yuan& Gong, Quan…[et al.]. 2016. The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108020
Modern Language Association (MLA)
Wang, Yanan…[et al.]. The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes. Journal of Diabetes Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108020
American Medical Association (AMA)
Wang, Yanan& Zhong, Jixin& Zhang, Xiangzhi& Liu, Ziwei& Yang, Yuan& Gong, Quan…[et al.]. The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108020